Molecular changes in invasive front of oral cancer.
Molecular changes in invasive front of oral cancer.
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DOI：
10.4103/0973-029x.119740
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发表时间：
2013-05
期刊：
影响因子：
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通讯作者：
Radhakrishnan R
中科院分区：
文献类型：
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作者：
Sharma M;Sah P;Sharma SS;Radhakrishnan R
口腔鳞状细胞癌(OSCC)的治疗计划是基于临床TNM(肿瘤、结节和转移)的分类。这个系统的运行假设是，没有临床扩散的小肿瘤比有转移的大肿瘤有更好的预后。然而，一些临床分期相同的肿瘤表现出不同的生长模式和临床行为，这是众所周知的事实。这使得仅凭临床分期很难预测口腔鳞癌患者的预后。尽管口腔鳞状细胞癌的许多组织病理学特征已被确定为预后因素，但没有一种被认为是完全错误的。因此，迫切需要更可靠的预后标记物，以帮助治疗决策。目前已有文献证明，一些对肿瘤扩散具有重要意义的分子事件，如黏附分子的获得和丢失，蛋白水解酶的分泌，细胞增殖的增加和血管生成的启动，发生在肿瘤-宿主界面或侵袭性最深的细胞所在的位置。该综述描述了发生在口腔鳞癌侵袭性前沿的各种分子事件和相互作用，并阐明了它们作为预后标志物的作用。
Treatment planning for oral squamous cell carcinoma (OSCC) is based on the clinical TNM (Tumor, Node and Metastasis) classification. This system operates on the assumption that small tumours without clinical spread have a better prognosis than larger tumours with metastases. However, it is a well-known fact that some tumours with the same clinical staging show different growth patterns and clinical behaviour. This makes the prognosis for patients with OSCC difficult to predict on the basis of clinical staging alone. Although many histopathological characteristics of OSCC have been identified as prognostic factors, none is believed to be completely infallible. Therefore, a great need exists for more reliable prognostic markers, which will assist in treatment decisions. It is now well documented that several molecular events of significance for tumour spread, such as gain and loss of adhesion molecules, secretion of proteolytic enzymes, increased cell proliferation and initiation of angiogenesis occur at the tumour–host interface or invasive front, where the deepest and presumably most aggressive cells reside. This review describes the various molecular events and interactions, which take place in the invasive front of the OSCC, and elucidates their role as prognostic markers.