Conjugated linoleic acid and other anticarcinogenic agents of bovine milk fat
Conjugated linoleic acid and other anticarcinogenic agents of bovine milk fat
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DOI：
10.3168/jds.s0022-0302(99)75358-0
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发表时间：
1999-06-01
影响因子：
3.5
通讯作者：
Parodi, PW
中科院分区：
文献类型：
--
作者：
Parodi, PW
预防是战胜癌症的重要策略。乳脂中含有多种成分，如共轭亚油酸、鞘磷脂、丁酸、醚脂、β-胡萝卜素以及具有抗癌潜力的维生素A和D。共轭亚油酸可抑制多种人类癌细胞系的生长，并在动物模型的多个部位抑制化学诱导的肿瘤发展。饮食中低至 0.1% 的共轭亚油酸即可抑制大鼠乳腺肿瘤的发展，与饮食中脂肪的数量和类型无关。鞘磷脂通过其代谢物神经酰胺和鞘氨醇参与与抑制癌发生相关的多种抗增殖途径。膳食鞘磷脂抑制小鼠结肠肿瘤的发展。丁酸独特地存在于反刍动物奶中，是一种有效的抗肿瘤剂，并且可以通过与其他乳脂成分的协同作用来提高其效力。膳食丁酸可抑制大鼠乳腺癌的发展。在人类中，醚脂、β-胡萝卜素以及维生素 A 和 D 具有抗癌作用。奶牛有能力从牧草和饲料中提取抗癌成分并将其转移到牛奶中。使用基因工程和其他技术来增加牧草和补充剂中抗癌物质的范围和水平，可能会增加牛奶的抗癌潜力。
Prevention is an important strategy for conquering cancer. Milk fat contains a number of components, such as conjugated linoleic acid, sphingomyelin, butyric acid, ether lipids, beta-carotene, and vitamins A and D that have anticancer potential. Conjugated linoleic acid inhibits the growth of a number of human cancer cell lines and suppresses chemically-induced tumor development at a number of sites in animal models. As little as 0.1% of dietary conjugated linoleic acid inhibits the development of rat mammary tumors, independent of the amount and type of fat in the diet. Sphingomyelin, through its metabolites ceramide and sphingosine, participates in multiple antiproliferative pathways associated with suppression of carcinogenesis. Dietary sphingomyelin inhibits murine colon tumor development. Butyric acid, uniquely present in ruminant milk, is a potent antineoplastic agent and may ameliorate its potency through synergy with other milk fat components. Dietary butyric acid inhibits mammary carcinoma development in rats. In humans, ether lipids, beta-carotene, and vitamins A and D are associated with anticancer effects. Cows have the ability to extract anticarcinogenic components from pasture and feed and transfer them to milk. Use of genetic engineering and other techniques to increase the range and level of anticarcinogens in pasture and supplements may increase the anticancer potential of milk.