Pholcodine caused anaphylaxis in Sweden 30 years ago
Pholcodine caused anaphylaxis in Sweden 30 years ago
复制标题
福尔可定 30 年前在瑞典引起过敏反应
DOI：
10.1111/j.1398-9995.2009.01983.x
复制
发表时间：
2009
期刊：
影响因子：
12.4
通讯作者：
E. Florvaag
中科院分区：
文献类型：
--
作者：
S. Johansson;H. Öman;A. Nopp;E. Florvaag
在粗藜麦提取物和加热藜麦提取物中，血清的表观分子质量为35 kDa（图1B）。对照血清未观察到特异性IgE结合（图1C）。对菠菜或甜菜的特殊食物过敏和对乳胶的交叉过敏已被报道（2-4）。CICBAA数据库1400例食物过敏患者无记录。主要的藜麦种子贮藏蛋白包括：11s型球蛋白chenopodin和高半胱氨酸2S部分。11s型种子蛋白由两组大小在30 - 40 kDa（酸性亚基）和20-25 kDa（碱性亚基）之间的多肽组成，它们通过二硫键连接在天然蛋白中，这是11s型种子蛋白的特征(5)。因此，免疫印迹法证实，35 kDa附近的条带可能属于chenopodin A酸性亚基。藜麦种子的高可溶性蛋白质可用于开发功能性食品，并可作为替代大豆或罗苹粉的潜在成分，另外还有避免强制性标签的优点(6)。由于这个原因，第一例记录了耐热过敏原的过敏反应是特别有趣的。
serum to one band with an apparent molecular mass of 35 kDa, in both crude and heated quinoa extracts (Fig. 1B). No specific IgE binding was observed for the control sera (Fig. 1C). Exceptional food allergies to spinach or beets and cross allergy to latex have been reported (2–4). No case is recorded in the CICBAA data bank including 1400 food allergic patients. The major quinoa seed storage proteins included: 11S-type globulins named chenopodin and a high-cysteine 2S fraction. Two heterogeneous sets of polypeptides in the size ranges 30– 40 kDa (acidic subunits) and 20–25 kDa (basic subunits) joined by disulphide bonds in the native protein characterize the 11S-type of seed proteins (5). The band near 35 kDa evidenced by immunoblot therefore may belong to the class of chenopodin A acidic subunits. Highly soluble proteins of quinoa seeds can be used for developing functional foods and as potential ingredients that could be substituted for soy or lupin flour, with additional advantage of avoiding mandatory labelling (6). For this reason, this first case of anaphylaxis documenting a thermostable allergen is of particular interest.