Obligate intracellular parasites:: Rickettsia prowazekii and Chlamydia trachomatis
Obligate intracellular parasites:: Rickettsia prowazekii and Chlamydia trachomatis
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DOI：
10.1016/s0014-5793(99)00563-3
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发表时间：
1999-06-04
期刊：
影响因子：
3.5
通讯作者：
Andersson, SGE
中科院分区：
文献类型：
--
作者：
Zomorodipour, A;Andersson, SGE
在过去的进化过程中，向专性细胞内寄生的转变已经发生了很多次。两种专性细胞内寄生虫——普瓦泽基立克次体和沙眼衣原体的基因组序列很快就被发表了。对这两个基因组的比较分析揭示了还原趋同进化的例子，例如涉及生物合成功能的基因的大量丢失。此外，这两个基因组都被发现编码 ATP 和 ADP 的运输系统，而这在细菌中是没有的。在这里，我们通过比较从最近发表的普罗瓦泽基衣原体和沙眼衣原体基因组序列中获得的信息来讨论对细胞内栖息地的适应。 (C) 1999 年欧洲生化学会联合会。
Transitions to obligate intracellular parasitism have occurred at numerous times in the evolutionary past, The genome sequences of two obligate intracellular parasites, Rickettsia prowazekii and Chlamydia trachomatis, were published fast year. A comparative analysis of these two genomes has revealed examples of reductive convergent evolution, such as a massive loss of genes involved in biosynthetic functions. In addition, both genomes were found to encode transport systems for ATP and ADP, not otherwise found in bacteria, Here, we discuss adaptations to intracellular habitats by comparing the information obtained from the recently published genome sequences of R. prowazekii and C. trachomatis. (C) 1999 Federation of European Biochemical Societies.