RELATIONSHIPS BETWEEN GAMMA-AMINOBUTYRATE AND SUCCINATE CYCLES DURING AND AFTER CEREBRAL-ISCHEMIA
RELATIONSHIPS BETWEEN GAMMA-AMINOBUTYRATE AND SUCCINATE CYCLES DURING AND AFTER CEREBRAL-ISCHEMIA
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DOI：
10.1002/jnr.490070210
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发表时间：
1982-01-01
影响因子：
4.2
通讯作者：
DOSSENA, M
中科院分区：
文献类型：
--
作者：
BENZI, G;PASTORIS, O;DOSSENA, M
一些代谢物（糖原、葡萄糖、G-6-P、丙酮酸、乳酸、柠檬酸、α-葡萄糖）酮戊二酸、琥珀酸、富马酸、苹果酸、谷氨酸、天冬氨酸、GABA、谷氨酰胺、丙氨酸、NH 4+）。完全缺血诱导糖酵解底物和中间体的下降，这与乳酸、琥珀酸、丙氨酸和GABA的增加以及苹果酸、富马酸和α-氨基丁酸的减少一致。酮戊二酸。这些事件可被视为GABA循环和琥珀酸循环的活化的表达，其中琥珀酸本身在不存在O2的情况下充当末端电子受体。在缺血后恢复期间，脑参数趋于正常化，除了丙氨酸的进一步增加以及琥珀酸和GABA的含量仍然高于正常之外，这是γ-氨基丁酸的可能激活的表现。谷氨酰和GABA循环。
Some metabolites (glycogen, glucose, G-6-P, pyruvate, lactate, citrate, .alpha.-ketoglutarate, succinate, fumarate, malate, glutamate, aspartate, GABA, glutamine, alanine, NH4+) were measured in rat cerebral cortex after 5 min of complete compression ischemia, and after 5, 15 or 30 min of recirculation following 5 min of ischemia. Complete ischemia induced a drop of glycolytic substrates and intermediates, consistent with the increase of lactate, succinate, alanine and GABA, and with the decrease of malate, fumarate and .alpha.-ketoglutarate. These events may be regarded as an expression of the activation of the GABA cycle and of the succinate cycle, where succinate itself, in the absence of O2, acts as a terminal electron acceptor. During post-ischemic recovery, cerebral parameters tended to normalize, except for the further increase of alanine and the still higher than normal content of both succinate and GABA, as an expression of the possible activation of the .gamma.-glutamyl and GABA cycles during recovery.