Integrin-mediated function of Rab GTPases in cancer progression.
Integrin-mediated function of Rab GTPases in cancer progression.
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DOI：
10.1186/1476-4598-9-312
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发表时间：
2010-12-09
期刊：
影响因子：
37.3
通讯作者：
Alahari SK
中科院分区：
文献类型：
--
作者：
Subramani D;Alahari SK
小gtpase的RAS（大鼠肉瘤）超家族大致可分为5组：RAS、Rho、Rab、Ran和Arf。Rab家族蛋白在调节信号转导和细胞过程（如分化、增殖、囊泡运输、核组装和细胞骨架形成）中起重要作用。然而，一些rabb蛋白已被报道为癌细胞的粘附和迁移所必需的。尽管Ras和Rho家族成员与癌症进展密切相关，但对Rabs在这方面的作用的了解有限。一些报道还将Rab gtp酶与癌细胞迁移和侵袭性联系起来。这篇综述讨论了Rabs通过整合素介导的信号事件参与恶性转化和癌症治疗的意义，特别强调了乳腺癌。
The RAS (rat sarcoma) superfamily of small GTPases is broadly subdivided into five groups: Ras, Rho, Rab, Ran, and Arf. Rab family proteins are important in regulating signal transduction and cellular processes such as differentiation, proliferation, vesicle transport, nuclear assembly, and cytoskeleton formation. However, some Rab proteins have been reported to be necessary for the adhesion and migration of cancer cells. Although Ras and Rho family members have been strongly implicated in cancer progression, knowledge of Rabs action in this regard is limited. Some reports have also linked Rab GTPases with cancer cell migration and invasiveness. This review discusses the implications of the involvement of Rabs in malignant transformation and cancer therapy through integrin-mediated signaling events, with particular emphasis on breast cancer.
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