Inhibition of nitric oxide synthase impairs a distinct form of long-term memory in the honeybee, Apis mellifera
Inhibition of nitric oxide synthase impairs a distinct form of long-term memory in the honeybee, Apis mellifera
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DOI：
10.1016/s0896-6273(00)80073-2
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发表时间：
1996-03-01
期刊：
影响因子：
16.2
通讯作者：
Muller, U
中科院分区：
文献类型：
--
作者：
Muller, U
一氧化氮已被证明与神经可塑性有关，而神经可塑性是学习和记忆过程的基础。在蜜蜂中，对一氧化氮在联想嗅觉学习中的作用的研究揭示了它在记忆形成中的特定功能。在嗅觉调节过程中，一氧化氮合酶的抑制会损害由于多次学习试验而形成的独特的长期记忆。一氧化氮合酶阻断不影响单次学习试验诱导的记忆的获得或恢复或记忆的形成。这一发现为解剖记忆形成的分子机制，特别是一氧化氮合酶的特殊功能，提供了第一步。
Nitric oxide has been shown to be implicated in neural plasticity that underlies processes of learning and memory. In the honeybee, studies on the role of nitric oxide in associative olfactory learning reveal its specific function in memory formation. Inhibition of nitric oxide synthase during olfactory conditioning impairs a distinct long-term memory that is formed as a consequence of multiple learning trials. Acquisition or retrieval of memory or memory formation induced by a single learning trial is not affected by blocking of nitric oxide synthase. This finding provides a first step toward dissection of molecular mechanisms involved in memory formation, in general, and the special function of nitric oxide synthase, in particular.