The course of persistent airflow limitation in subjects with and without asthma.
The course of persistent airflow limitation in subjects with and without asthma.
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DOI：
10.1016/j.rmed.2008.04.011
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发表时间：
2008-10
影响因子：
4.3
通讯作者：
Martinez, Fernando D.
中科院分区：
文献类型：
--
作者：
Guerra, Stefano;Sherrill, Duane L.;Kurzius-Spencer, Margaret;Venker, Claire;Halonen, Marilyn;Quan, Stuart F.;Martinez, Fernando D.
大多数出现持续性气流受限的患者要么是慢性阻塞性肺病的表现（很大程度上与吸烟有关），要么是持续性哮喘的结果。我们试图比较患有和不患有哮喘的受试者从成年早期到成年后期与持续气流受限相关的肺功能自然过程。我们研究了 2552 名 25 岁或以上的参与者，他们拥有来自图森气道阻塞性疾病长期前瞻性人群流行病学研究的多项问卷和肺功能数据。持续气流受限定义为在第一次气流受限调查后所有已完成的调查中，FEV1/FVC 比率始终< 70%。根据医生确认的哮喘状况（从未、发病≤25年或发病>25年）和研究随访期间是否存在气流受限（从未、不一致或持续），将参与者分为九组。在哮喘发病年龄≤25岁的受试者中，血液嗜酸性粒细胞增多显着增加了发生持续气流受限的几率（调整比：3.7、1.4-9.5），而吸烟是非哮喘患者和25岁后哮喘发作的受试者中持续气流受限的最强危险因素。在持续气流受限的受试者中，哮喘发病时间≤25岁的受试者和非哮喘受试者的肺功能自然过程有所不同，前者在25岁时的FEV1水平较低（175厘米高男性的预测值分别为3,400毫升和4,090毫升；p<0.001），而后者在25岁至75岁时的FEV1损失更大（1,590毫升对1,590毫升） 2,140 毫升；p=0.003)。对于 25 岁之前出现哮喘并在成年后持续出现气流受限的受试者，大部分 FEV1 缺陷在 25 岁之前就已形成。
Most patients who develop persistent airflow limitation do so either as a manifestation of chronic obstructive pulmonary disease that is largely related to smoking or as a consequence of persistent asthma. We sought to compare the natural course of lung function associated with persistent airflow limitation in subjects with and without asthma from early to late adult life. We studied 2552 participants aged 25 or more who had multiple questionnaire and lung function data from the long-term prospective population-based Tucson Epidemiological Study of Airway Obstructive Disease. Persistent airflow limitation was defined as FEV1/FVC ratio consistently < 70% in all completed surveys subsequent to the first survey with airflow limitation. Participants were divided into nine groups based on the combination of their physician-confirmed asthma status (never, onset ≤ 25 years, or onset > 25 years) and the presence of airflow limitation during the study follow-up (never, inconsistent, or persistent). Among subjects with an asthma onset ≤ 25 years, blood eosinophilia increased significantly the odds of developing persistent airflow limitation (adjOR: 3.7, 1.4–9.5), whereas cigarette smoking was the strongest risk factor for persistent airflow limitation among non-asthmatics and among subjects with asthma onset after age 25 years. Among subjects with persistent airflow limitation, the natural course of lung function differed between subjects with asthma onset ≤ 25 years and non-asthmatics, with the former having lower FEV1 levels at age 25 (predicted value for a 175-cm tall male of 3,400 versus 4,090 ml, respectively; p<0.001) and the latter having greater FEV1 loss between age 25 and 75 (1,590 versus 2,140 ml; p=0.003). In subjects who have asthma onset before 25 years of age and persistent airflow limitation in adult life, the bulk of the FEV1 deficit is already established before age 25 years.
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影响因子：
14.2
作者：
de Marco, Roberto;Marcon, Alessandro;Janson, Christer
通讯作者：
Janson, Christer
DOI：
10.1164/ajrccm.160.6.9811041
发表时间：
1999-12-01
影响因子：
24.7
作者：
Hospers, JJ;Schouten, JP;Postma, DS
通讯作者：
Postma, DS
影响因子：
5
作者：
LEBOWITZ, MD;KNUDSON, RJ;BURROWS, B
通讯作者：
BURROWS, B
DOI：
10.1164/ajrccm.159.4.9807121
发表时间：
1999-04-01
影响因子：
24.7
作者：
Hansen, EF;Phanareth, K;Dirksen, A
通讯作者：
Dirksen, A
影响因子：
158.5
作者：
Celli, BR;Cote, CG;Cabral, HJ
通讯作者：
Cabral, HJ