A computational model for the loss of neuronal organization in microcolumns.
A computational model for the loss of neuronal organization in microcolumns.
复制标题
微柱中神经元组织损失的计算模型。
DOI：
10.1016/j.bpj.2014.04.012
复制
发表时间：
2014
影响因子：
3.4
通讯作者：
Cruz,Luis
中科院分区：
文献类型：
--
作者：
Henderson,Maxwell;Urbanc,Brigita;Cruz,Luis
人类和其他哺乳动物大脑皮层中的一群神经元将自身组织成垂直于软脑膜表面的垂直微柱。这些微柱的解剖学变化与神经系统疾病和正常衰老有关。特别是，在恒河猴大脑的 46 区域，微柱的强度随着年龄的增长而降低。这些变化可能是由微柱中神经元空间分布的改变和/或神经元损失引起的。使用源自薄组织切片并在恒河猴脑组织中验证的神经元排列的三维计算模型，我们发现神经元损失与老年人的发现不一致。相比之下，简单随机神经元位移模型（其大小受到恢复谐波力的限制）与观察到的变化一致，并为年龄引起的微柱结构损失提供了机制见解。讨论了该模型与正常衰老和疾病的联系。
A population of neurons in the cerebral cortex of humans and other mammals organize themselves into vertical microcolumns perpendicular to the pial surface. Anatomical changes to these microcolumns have been correlated with neurological diseases and normal aging; in particular, in area 46 of the rhesus monkey brain, the strength of microcolumns was shown to decrease with age. These changes can be caused by alterations in the spatial distribution of the neurons in microcolumns and/or neuronal loss. Using a three-dimensional computational model of neuronal arrangements derived from thin tissue sections and validated in brain tissue from rhesus monkeys, we show that neuronal loss is inconsistent with the findings in aged individuals. In contrast, a model of simple random neuronal displacements, constrained in magnitude by restorative harmonic forces, is consistent with observed changes and provides mechanistic insights into the age-induced loss of microcolumnar structure. Connection of the model to normal aging and disease are discussed.