Glucose Tolerance Affects Pubertal Growth and Final Height of Children With Cystic Fibrosis
Glucose Tolerance Affects Pubertal Growth and Final Height of Children With Cystic Fibrosis
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DOI：
10.1002/ppul.23042
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发表时间：
2015-02-01
影响因子：
3.1
通讯作者：
Lucidi, Vincenzina
中科院分区：
文献类型：
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作者：
Bizzarri, Carla;Montemitro, Enza;Lucidi, Vincenzina
囊性纤维化相关糖尿病(CFRD)对生长的影响的数据很少。我们分析了17例囊性纤维化(CF)儿童在青春期新诊断的CFRD，并与52名正常糖耐量(NGT)的囊性纤维化儿童进行了对照。人体测量学评估显示，CFRD诊断时的体重指数显著低于NGT儿童(CFRD：-0.48+/-1.08 vs.NGT：0.2+/-0.99；P=0.01)，在随访结束时差异仍然明显(CFRD：-0.49+/-0.95 vs.NGT：0.13+/-0.89；P=0.04)。正常儿童基线身高标准差得分略低于正常对照组(-0.71+/-0.83vs.NGT：-0.25+/-1.08；P=0.08)，而最终身高标准差显著降低(正常对照组：-0.61+/-1.12vs正常对照组：-0.61+/-1.15；P=0.003)。全组平均身高标准差低于平均目标身高标准差(最终身高标准差：-0.86+/-1.2，目标身高标准差：-0.3+/-0.85；P
There are few data about the impact of cystic fibrosis-related diabetes (CFRD) on growth. We analyzed 17 children with cystic fibrosis (CF) presenting with newly diagnosed CFRD during puberty, in comparison with a matched control group of 52 CF children with normal glucose tolerance (NGT). Anthropometric evaluation showed that body mass index at CFRD diagnosis was significantly reduced in children with CFRD, in comparison with children with NGT (CFRD: -0.48 +/- 1.08 vs. NGT: 0.2 +/- 0.99; P=0.01), and the same difference remained evident at the end of follow up (CFRD: -0.49 +/- 0.95 vs. NGT: 0.13 +/- 0.89; P=0.04). Height standard deviation score (SDS) at baseline was slightly but not significantly lower in CFRD children (CFRD: -0.71 +/- 0.83 vs. NGT: -0.25 +/- 1.08; P=0.08), while final height SDS was significantly reduced (CFRD: -1.61 +/- 1.12 vs. NGT: -0.61 +/- 1.15; P=0.003). Mean final height SDS of the whole group was lower than mean target height SDS (final height SDS: -0.86 +/- 1.2 vs. target height SDS: -0.3 +/- 0.85; P