Effect of verapamil on plasma parathyroid hormone.
Effect of verapamil on plasma parathyroid hormone.
复制标题
维拉帕米对血浆甲状旁腺激素的影响。
DOI：
--
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
J. Levi
中科院分区：
文献类型：
--
作者：
E. Bogin;A. Chagnac;H. Jüppner;J. Levi
在正常和尿毒症雄性Wistar大鼠中研究了钙拮抗剂维拉帕米对甲状旁腺激素行为的影响。甲状旁腺切除术采用烧灼法。通过双侧肾切除术诱导急性尿毒症，通过皮下注射诱导中度尿毒症。注射庆大霉素（200 mg/kg）。皮下注射乙二胺四乙酸（50 mg/kg × d）。甲状旁腺激素测定采用放射免疫法。根据血浆尿素水平确定尿毒症程度。肾衰竭导致血浆甲状旁腺激素显著升高（平均值+/- SEM，ng/l）（对照组84 +/- 6，n = 10;中度尿毒症组277 +/- 39，n = 7;急性尿毒症组667 +/- 128，n = 6）。注射维拉帕米显著增加血浆甲状旁腺激素水平，范围从对照组的21%到中度尿毒症组的62%。在急性尿毒症患者中，甲状旁腺激素水平非常高，维拉帕米没有引起血液中甲状旁腺激素的进一步升高。甲状旁腺切除术显著降低血浆甲状旁腺激素，维拉帕米导致平均增加29%。与对照组相比，EDTA引起64%的增加。
The effects of the Ca antagonist, verapamil, on the behaviour of parathyroid hormone was studied in normal and uraemic male Wistar rats. Parathyroidectomy was by cautery. Acute uraemia was induced by bilateral nephrectomy, and moderate uraemia by s.c. injection of gentamicin (200 mg/kg). Ethylendiamine tetracetic acid (50 mg/kg X d) was injected subcutaneously. Parathyroid hormone was determined by radioimmunoassay. The degree of uraemia was determined from plasma urea levels. Renal failure resulted in a significant increase in plasma parathyroid hormone (mean +/- SEM, ng/l) (84 +/- 6, n = 10, in the control; 277 +/- 39, n = 7, in the moderate uraemics and 667 +/- 128, n = 6, in the acute uraemics). Injection of verapamil significantly increased plasma levels of parathyroid hormone, ranging from 21% in the controls to 62% in the moderate uraemia group. In the acute uraemics, parathyroid hormone levels were very high and verapamil did not cause any further elevation of the hormone in the blood. Parathyroidectomy significantly lowered plasma parathyroid hormone, and verapamil resulted in a mean increase of 29%. EDTA caused an increase of 64%, compared with the control group.