Prevalence of and Factors Associated With Persistent Pain Following Breast Cancer Surgery
Prevalence of and Factors Associated With Persistent Pain Following Breast Cancer Surgery
复制标题
DOI：
10.1001/jama.2009.1568
复制
发表时间：
2009-11-11
影响因子：
120.7
通讯作者：
Kehlet, Henrik
中科院分区：
文献类型：
--
作者：
Gartner, Rune;Jensen, Maj-Britt;Kehlet, Henrik
乳腺癌手术治疗后持续的疼痛和感觉障碍是一个重要的临床问题。其发病机制复杂，可能与患者的特点、手术技术和辅助治疗有关。目的探讨乳腺癌手术治疗后持续性疼痛的患病率和相关因素。对3754名年龄在18至70岁之间接受手术和辅助治疗的女性进行了一项全国性的横断面问卷调查研究。（如有指征）2005年1月1日至2006年12月31日期间在丹麦接受原发性乳腺癌治疗。研究问卷于2008年1月至4月间发送给女性。主要结果测量12个明确定义的治疗组中持续疼痛和感觉障碍的患病率，位置和严重程度，评估术后平均26个月，并调整年龄，手术技术，化疗，结果截至2008年6月，3754名符合条件的妇女中有3253名（87%）返回了问卷。共有1543例患者（47%）报告疼痛，其中201例（13%）为重度疼痛，595例（39%）为中度疼痛，733例（48%）为轻度疼痛。与慢性疼痛相关的因素包括年轻（18-39岁：OR，3.62; 95%置信区间[CI]，2.25-5.82; P
Context Persistent pain and sensory disturbances following surgical treatment for breast cancer is a significant clinical problem. The pathogenic mechanisms are complex and may be related to patient characteristics, surgical technique, and adjuvant therapy.Objective To examine prevalence of and factors associated with persistent pain after surgical treatment for breast cancer.Design, Setting, and Patients A nationwide cross-sectional questionnaire study of 3754 women aged 18 to 70 years who received surgery and adjuvant therapy (if indicated) for primary breast cancer in Denmark between January 1, 2005, and December 31, 2006. A study questionnaire was sent to the women between January and April 2008.Main Outcome Measures Prevalence, location, and severity of persistent pain and sensory disturbances in 12 well-defined treatment groups assessed an average of 26 months after surgery, and adjusted odds ratio (OR) of reported pain and sensory disturbances with respect to age, surgical technique, chemotherapy, and radiotherapy.Results By June 2008, 3253 of 3754 eligible women (87%) returned the questionnaire. A total of 1543 patients (47%) reported pain, of whom 201 (13%) had severe pain, 595 (39%) had moderate pain, and 733 (48%) had light pain. Factors associated with chronic pain included young age (18-39 years: OR, 3.62; 95% confidence interval [CI], 2.25-5.82; P