Cutaneous tuberculosis. Part II: Complications, diagnostic workup, histopathologic features, and treatment
Cutaneous tuberculosis. Part II: Complications, diagnostic workup, histopathologic features, and treatment
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DOI：
10.1016/j.jaad.2021.12.064
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发表时间：
2023-11-10
影响因子：
13.8
通讯作者：
Singal, Archana
中科院分区：
文献类型：
--
作者：
Kaul, Subuhi;Jakhar, Deepak;Singal, Archana
尽管皮肤结核病有有效的治疗方案，但延误诊断、感染多药耐药分支杆菌菌株以及与艾滋病毒合并感染对疾病控制构成挑战。如果皮肤科医生对感染的临床体征和症状敏感，并结合适当的诊断试验，可以减少延误的诊断。所有的皮肤结核病例都应该通过组织病理学和培养来确认，无论是否有分子检测。在每一种情况下，都有必要对系统性参与进行彻底评估。分枝杆菌可能不是从皮肤结核病变中分离出来的，因此，可能需要进行抗结核治疗试验才能确认诊断。本继续医学教育系列的第二篇文章描述了结核病的后遗症、组织病理学和治疗。
Despite the availability of effective treatment regimens for cutaneous tuberculosis, challenges to disease control result from delayed diagnosis, infection with multidrug-resistant mycobacterial strains, and coinfection with HIV. Delayed diagnosis can be mitigated when dermatologists are sensitized to the clinical signs and symptoms of infection and by the incorporation of appropriate diagnostic tests. All cases of cutaneous tuberculosis should be confirmed with histopathology and culture with or without molecular testing. In each case, a thorough evaluation for systemic involvement is necessary. Mycobacteria may not be isolated from cutaneous tuberculosis lesions and therefore, a trial of antituberculosis treatment may be required to confirm the diagnosis. The second article in this 2-part continuing medical education series describes the sequelae, histopathology, and treatment of tuberculosis