NaH promoted [4+3] annulation of crotonate-derived sulfur ylides with thioaurones: synthesis of 2,5-dihydrobenzo[4,5]thieno[3,2-b]oxepines.
NaH promoted [4+3] annulation of crotonate-derived sulfur ylides with thioaurones: synthesis of 2,5-dihydrobenzo[4,5]thieno[3,2-b]oxepines.
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DOI：
10.1039/c7cc04466f
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发表时间：
2017-09
影响因子：
4.9
通讯作者：
You-Cai Zhang;A. Yu;Jiru Jia;Shanshan Ma;Keyi Li;Yin Wei;Xiangtai Meng
中科院分区：
文献类型：
--
作者：
You-Cai Zhang;A. Yu;Jiru Jia;Shanshan Ma;Keyi Li;Yin Wei;Xiangtai Meng
首次报道了巴豆酸衍生的硫叶立德与硫代金酮在NaH碱作用下的[4+3]成环反应。以良好至优异的产率获得各种各样的2，5-二氢苯并[4，5]噻吩并[3，2-B]氧杂环庚三烯。所提出的机制进行了调查和支持DFT计算。
The [4+3] annulation reaction of crotonate-derived sulfur ylides with thioaurones has, for the first time, been reported using NaH as the base. A diverse array of 2,5-dihydrobenzo[4,5]thieno[3,2-b]oxepines is obtained in good to excellent yields. The proposed mechanism is investigated and supported by DFT calculations.