Possible prevention of fulminant hepatic failure in four children with acute severe hepatitis
Possible prevention of fulminant hepatic failure in four children with acute severe hepatitis
复制标题
可能预防四名急性重型肝炎儿童发生暴发性肝衰竭
DOI：
10.1007/s00535-003-1310-9
复制
发表时间：
2004
影响因子：
6.3
通讯作者：
K. Isoyama
中科院分区：
文献类型：
--
作者：
M. Yoshiba;M. Yamada;Kazuaki Inoue;Tsunamasa Watanabe;S. Kanesaka;K. Isoyama
致编辑：原位活体肝移植（LTx）提高了儿童暴发性肝功能衰竭（FHF）的存活率。然而，除了接受LTx的机会比非急诊疾病小之外，FHF合并LTx的生存率也低于其他疾病。1，2我们报道了一名9个月大的C型暴发性肝炎（FH）婴儿成功地用干扰素（IFN）和环孢菌素A（CsA）治疗，该婴儿符合国王学院提出的LTx标准。3.提示IFN和免疫抑制剂联合治疗儿童FH是可行的。4我们报道了在急性重型肝炎（ASH）阶段准确预测FHF。5如果在这个阶段开始治疗，康复的机会可能会进一步增加。在这篇文章中，我们报告了成功的治疗，使用干扰素和免疫抑制剂，四名儿童与ASH可能的病毒原因谁被怀疑发展FHF。
To the Editor: Orthotopic and living-related liver transplantation (LTx) has increased the survival rate of fulminant hepatic failure (FHF) in children. However, in addition to the fact that the chance of receiving LTx is smaller compared with that in nonemergency diseases, the survival rate of FHF with LTx is lower than that in other diseases. 1, 2We have reported successful treatment, with interferon (IFN) and cyclosporin A (CsA), in a 9-month-old baby with type-C fulminant hepatitis (FH) who met the criteria for LTx proposed by the Kings College. 3 Thus, we suggested that child FH may be successfully treated with IFN and immunosuppressive agents. 4 We have reported that FHF is accurately predicted at the stage of acute severe hepatitis (ASH). 5 If the treatment is started at this stage, the chance of recovery may be further increased. In this communication, we report the successful treatment, using IFN and immunosuppressive agents, of four children with ASH of probable viral causes who were suspected of developing FHF.