Generation of cloned transgenic pigs rich in omega-3 fatty acids
Generation of cloned transgenic pigs rich in omega-3 fatty acids
复制标题
DOI：
10.1038/nbt1198
复制
发表时间：
2006-04-01
影响因子：
46.9
通讯作者：
Dai, YF
中科院分区：
文献类型：
--
作者：
Lai, LX;Kang, JX;Dai, YF
肉类产品中的ω-3（n-3）脂肪酸含量一般较低，对人体健康有益。我们描述了一代的克隆猪表达的人源化秀丽隐杆线虫基因，脂肪-1，编码的n-3脂肪酸去饱和酶。hfat-1转基因猪从n-6类似物产生高水平的n-3脂肪酸，并且它们的组织具有显著降低的n-6/n-3脂肪酸比率（P < 0.001）。
Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001).