Restricted expression of fgf16 within the developing chick inner ear
Restricted expression of fgf16 within the developing chick inner ear
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DOI：
10.1002/dvdy.20872
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发表时间：
2006-08-01
影响因子：
2.5
通讯作者：
Schoenwolf, Gary C.
中科院分区：
文献类型：
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作者：
Chapman, Susan C.;Cai, Qin;Schoenwolf, Gary C.
成纤维细胞生长因子（FGF）信号传导是耳基板诱导和发育中的内耳的模式化所必需的。我们克隆了Fgf 16的鸡同源基因，并分析了其在早期鸡胚中的表达模式。表达仅限于耳基板和发育中的内耳通过检查的所有阶段。在闭合的耳囊阶段，表达已经分解到与骨形态发生蛋白4（Bmp4）部分重叠的前域和后域，骨形态发生蛋白4（Bmp4）是发育中的感觉斑、前半规管和后半规管的嵴的标记物。血小板衍生生长因子α（PDGFA），另一种耳表达受限的生长因子，也与Fgf16表达重叠。Fgf16的限制性表达模式表明FGF信号传导与BMP信号传导一起在感觉嵴的图案化中起作用。
Fibroblast growth factor (FGF) signaling is required for otic placode induction and patterning of the developing inner ear. We have cloned the chick ortholog of Fgf16 and analyzed its expression pattern in the early chick embryo. Expression is restricted to the otic placode and developing inner ear through all the stages examined. By the closed otocyst stage, expression has resolved to anterior and posterior domains that partially overlap with those of bone morphogenetic protein 4 (Bmp4), a marker of the developing sensory patches, the cristae of the anterior and posterior semicircular canals. Platelet-derived growth factor alpha (PDGFA), another growth factor with restricted otic expression, also overlaps with Fgf16 expression. The restricted expression pattern of Fgf16 suggests a role for FGF signaling in the patterning of the sensory cristae, together with BMP signaling.