Sterile wounding is a minimal and sufficient trigger for a cellular immune response in Drosophila melanogaster
Sterile wounding is a minimal and sufficient trigger for a cellular immune response in Drosophila melanogaster
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DOI：
10.1016/j.imlet.2005.03.021
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发表时间：
2005-10-15
影响因子：
4.4
通讯作者：
Andó, I
中科院分区：
文献类型：
--
作者：
Márkus, R;Kurucz, T;Andó, I
寄生蜂Leptopilina boulardi的攻击和产卵诱导了果蝇幼虫强烈的细胞免疫应答。这种反应表现为血细胞的一个专门的子集，即片状细胞的出现，它们是包裹和杀死寄生虫的关键参与者。板层细胞的形成涉及Toll、Jun激酶和JAK/STAT途径的激活，然而，在细胞免疫应答过程中启动板层细胞发育的最低要求尚未确定。在这项研究中，我们测试了是否机械损伤本身，产卵引起的，可以提供一个足够的信号，片层细胞的发展。我们发现，不育的创伤，产卵过程中发生的，诱导正常的片层细胞的发展。因此，我们建议，机械损伤的角质层和随后的破坏的基底层是一个最小的和足够的单一信号正常lamellocyte发展的过程中的细胞免疫反应的果蝇。(c)2005 Elsevier B. V.保留所有权利。
An attack and oviposition by parasitic wasp Leptopilina boulardi induces a vigorous cellular immune response in Drosophila melanogaster larvae. This response is manifested by the appearance of a specialized subset of blood cells, the lamellocytes, which are the key players in the encapsulation and killing of the parasite. The formation of lamellocytes involves the activation of the Toll, the Jun kinase and the JAK/STAT pathways however the minimal requirement for initiation of lamellocyte development in the course of the cellular immune response has not been defined yet. In this study, we tested whether or not the mechanical injury itself, caused by oviposition, could provide a sufficient signal for lamellocyte development. We found that sterile wounding, comparable to that occurring during oviposition, induces normal lamellocyte development. We propose therefore that mechanical damage of the cuticle and subsequent disruption of the basal lamina is a minimal and sufficient single signal for normal lamellocyte development in the course of the cellular immune response of Drosophila. (c) 2005 Elsevier B.V. All rights reserved.