Impact of smoked cannabis on tobacco cigarette smoking intensity and subjective effects: A placebo-controlled, double-blind, within-subjects human laboratory study.
Impact of smoked cannabis on tobacco cigarette smoking intensity and subjective effects: A placebo-controlled, double-blind, within-subjects human laboratory study.
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DOI：
10.1037/pha0000391
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发表时间：
2021-08
影响因子：
2.3
通讯作者：
Pickworth WB
中科院分区：
文献类型：
--
作者：
Peters EN;Herrmann ES;Smith C;Wilhelm JA;Koszowski B;Halquist M;Kosmider L;Poklis J;Roth S;Bart S;Pickworth WB
大麻和烟草的共同使用者经常在一次场合中按顺序使用大麻，然后使用烟草香烟，即，他们用烟草香烟“追逐”吸食的大麻。这项安慰剂对照、双盲、受试者体内人体实验室研究的目的是收集关于吸食大麻与安慰剂大麻如何影响吸烟行为、渴望和主观影响的初步数据。成人每日大麻和烟草共同使用者（N = 9）被随机分配到两个实验访问顺序（即活性大麻（5.2％THC）第一次访问和安慰剂大麻第二次访问，反之亦然）。参与者吸一支大麻香烟，大约 30 分钟后有 5 分钟的时间随意吸一支自己品牌的烟草香烟。正如预期的那样，活性大麻和安慰剂大麻条件下血浆四氢大麻酚水平的提高和大麻相关的主观影响有所不同。烟草抽吸地形测量和烟草渴望在大麻条件下没有差异，但参与者之间的累积总抽吸量似乎存在异质性。与吸食安慰剂相比，在调整吸烟前水平后，吸烟的主观影响的变化并不显着。结果并不支持吸食大麻的直接影响会改变吸烟行为的观点。大麻和吸烟之间的强烈重叠可能无法主要由药理学因素来解释，但可能是由涉及药理学过程和学习因素的更微妙和复杂的机制驱动的。
Co-users of cannabis and tobacco frequently use cannabis, then tobacco cigarettes, in a sequential pattern within an occasion, i.e., they “chase” smoked cannabis with a tobacco cigarette. The objective of this placebo-controlled, double-blind, within-subjects human laboratory study was to gather preliminary data on how smoking active vs. placebo cannabis impacts tobacco cigarette smoking behavior, craving, and subjective effects. Adult daily cannabis and tobacco co-users (N=9) were randomly assigned to two experimental visit orders (i.e., active cannabis (5.2% THC) first visit and placebo cannabis second visit, or vice versa). Participants smoked one cannabis cigarette, and approximately 30 minutes later were given a 5-minute ad libitum period to smoke one of their own brand of tobacco cigarette. As expected, boost in plasma THC levels and cannabis-related subjective effects differed between active and placebo cannabis conditions. Tobacco cigarette puff topography measures and tobacco craving did not differ between cannabis conditions, but there appeared to be between-participant heterogeneity in cumulative total puff volume. After smoking active vs. placebo cannabis, the changes in subjective effects of tobacco smoking after adjusting for pre-tobacco smoking levels were not significant. Results do not support the notion that immediate effects of smoked cannabis change the behavior of tobacco smoking. The strong overlap between cannabis and tobacco smoking may not be explained by primarily pharmacological factors, but may be driven by more nuanced and complex mechanisms involving pharmacological processes as well as learning factors.
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影响因子：
6.7
作者：
MELLO, NK;MENDELSON, JH;KUEHNLE, JC
通讯作者：
KUEHNLE, JC
影响因子：
4.2
作者：
Cooper, Ziva D.;Haney, Margaret
通讯作者：
Haney, Margaret
成人目前吸烟 - 美国，2016年。
DOI：
10.15585/mmwr.mm6702a1
发表时间：
2018-01-19
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Jamal A;Phillips E;Gentzke AS;Homa DM;Babb SD;King BA;Neff LJ
通讯作者：
Neff LJ
影响因子：
12.7
作者：
Goodwin, Renee D.;Pacek, Lauren R.;Hasin, Deborah S.
通讯作者：
Hasin, Deborah S.
影响因子：
6.7
作者：
HENNINGFIELD, JE;CHAIT, LD;GRIFFITHS, RR
通讯作者：
GRIFFITHS, RR