TIMP-1 Mediates Inflammatory and Immune Response to IL-6 in Adult Orbital Xanthogranulomatous Disease
TIMP-1 Mediates Inflammatory and Immune Response to IL-6 in Adult Orbital Xanthogranulomatous Disease
复制标题
TIMP-1 介导成人眼眶黄色肉芽肿病中对 IL-6 的炎症和免疫反应
DOI：
10.1080/09273948.2019.1581227
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发表时间：
2019-04-12
影响因子：
3.3
通讯作者：
Li, Jin
中科院分区：
文献类型：
--
作者：
Ding, Xia;Cao, Yuan;Li, Jin
摘要目的：目的探讨TIMP-1在成人眼眶黄色肉芽肿病（AOXGD）中的作用机制。AOXGD是一种罕见的非朗格汉斯组织细胞增生症，严重损害患者的外观和生活质量。我们回顾了22例AOXGD患者的临床表现和组织学分析，采用q-PCR和免疫组化方法检测TIMP-1和IL-6在AOXGD组织中的表达，并探讨IL-6诱导TIMP-1表达的可能机制。结果：AOXGD组织中IL-6和TIMP-1水平明显升高。IL-6通过刺激JAK 2和STAT 3的磷酸化促进M1巨噬细胞产生TIMP-1。此外，在AOXGD中，Th 1和Th 17细胞的经典标志物IL-17和IFN-γ增加。结论：提示IL 6 ~ JAK 2/STAT 3-TIMP-1信号通路在AOXGD中被激活，适应性Th 1和Th 17应答参与了AOXGD的发生发展。
Abstract Purpose: To explore the pathogenesis that TIMP-1 mediated in adult orbital xanthogranulomatous disease (AOXGD), a rare type of non-Langerhans histiocytosis that damages the appearance and quality of life of patients Methods: We reviewed 22 patients diagnosed with AOXGD based on clinical manifestations and histological analysis, and then investigated the expression of TIMP-1 and IL-6 with q-PCR and IHC in AOXGD tissues and the possible mechanism involved in the induction of TIMP-1 by IL-6. Results: IL-6 and TIMP-1 were significantly increased in AOXGD tissues. IL-6 promoted TIMP-1 production by M1 macrophages by stimulating the phosphorylation of JAK2 and STAT3. Moreover, IL-17 and IFN-γ, the classical markers of Th1 and Th17 cells, were increased in AOXGD. Conclusion: These data implied that the IL6~JAK2/STAT3-TIMP-1 signalling pathway is activated in AOXGD and that adaptive Th1 and Th17 responses are involved in the development of AOXGD.