Gastrointestinal-Renal Axis: Role in the Regulation of Blood Pressure.
Gastrointestinal-Renal Axis: Role in the Regulation of Blood Pressure.
复制标题
胃肠肾轴：调节血压的作用。
DOI：
10.1161/jaha.117.005536
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发表时间：
2017-03-06
影响因子：
5.4
通讯作者：
Zeng C
中科院分区：
文献类型：
--
作者：
Yang J;Jose PA;Zeng C
高血压是全世界最常见和最重要的健康问题之一。 1 据估计，到 2025 年，全球 29% 的成年人口，即 15.6 亿人将患有高血压。 2 高血压的患病率及其不良后果给高、中、低收入国家的高血压患者带来了沉重的负担。 2, 3 已报道许多高血压的单基因原因。然而，确定原发性高血压的病因一直受到阻碍，因为它是一种复杂的疾病，具有遗传、表观遗传和环境决定因素。在众多的环境因素中，钠的摄入量被认为是一个重要的因素。钠对于细胞稳态和液体平衡至关重要。然而，由于饮食摄入量增加和/或排泄受损而导致体内钠过多，是高血压最常见的危险因素。 4 有大量证据表明膳食钠摄入量过高会增加发生高血压的风险并导致心血管结局恶化。 4, 5 钠摄入过量也会减弱许多抗高血压药物的有益作用，包括肾素-血管紧张素系统 (RAS) 阻滞剂。 6 适度减少膳食盐摄入量会导致高血压和血压正常人群的血压显着下降。 7 因此，低钠饮食是高血压防治的主要方案。 8
Hypertension is one of the most common and important health problems worldwide. 1 It has been estimated that 29% of the world’s adult population, or 1.56 billion people, will have hypertension by the year 2025. 2 The prevalence of high blood pressure and its adverse consequences result in a heavy burden for hypertensive patients from high-, middle-, and low-income countries. 2, 3 Many monogenic causes of hypertension have been reported. However, determining the causes of essential hypertension has been hampered because it is a complex disorder with genetic, epigenetic, and environmental determinants. Among numerous environmental factors, sodium intake is thought to be an important one. Sodium is essential for cellular homeostasis and fluid balance. However, excessive sodium in the body, as a consequence of increased dietary intake and/or impaired excretion, is the most common risk factor for hypertension. 4 There is overwhelming evidence that high dietary sodium intake increases the risk for incident hypertension and leads to worse cardiovascular outcomes. 4, 5 Excess sodium intake also attenuates the beneficial effects of many antihypertensive drugs, including blockers of the renin–angiotensin system (RAS). 6 A modest reduction in dietary salt intake causes a significant fall in blood pressure in both hypertensive and normotensive individuals. 7 Therefore, a low-sodium diet is a major preventive and treatment scheme for hypertension. 8
DOI：
10.1016/j.bbamcr.2012.04.015
发表时间：
2012-07
影响因子：
5.1
作者：
Wang, Lijun;Li, Wennan;Kong, Shumin;Wu, Peng;Zhang, Chengbiao;Gu, Li;Wang, Mingxiao;Wang, WenHui;Gu, Ruimin
通讯作者：
Gu, Ruimin