Donor-recipient combinations of group A and BKIR haplotypes and HLA class I ligand affect the outcome of HLA-matched, sibling donor hematopoietic cell transplantation
Donor-recipient combinations of group A and BKIR haplotypes and HLA class I ligand affect the outcome of HLA-matched, sibling donor hematopoietic cell transplantation
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DOI：
10.1016/j.humimm.2007.01.019
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发表时间：
2007-05-01
期刊：
影响因子：
2.7
通讯作者：
Parham, Peter
中科院分区：
文献类型：
--
作者：
McQueen, Karina L.;Dorighi, Kristel M.;Parham, Peter
研究了供体和受体杀伤细胞免疫球蛋白样受体（KIR）基因型对人类白细胞抗原（HLA）匹配的同胞间造血细胞移植结果的影响。根据移植供体和受体中A组和B组KIR单倍型的组合，将移植分为四组。髓系患者的总生存率因KIR基因型组合而异。最佳生存率与供体缺乏而受体具有B组KIR单倍型相关；最差生存率与供体具有而受体缺乏B组KIR单倍型相关。后一种组合还与复发增加和急性移植物抗宿主病（GVHD）相关。然而，其有害影响仅见于受体和供体对C1 KIR配体纯合，因而缺乏C2配体的移植。Bw4配体的存在也与急性GVHD增加相关。相反，KIR3DL1及其同源Bw4配体同时存在与非复发死亡率降低相关。对KIR基因的单独分析显示，KIR2DS3是慢性GVHD的一个保护因素。研究结果表明，对KIR基因型的简单评估如何能够为造血细胞移植供体的选择提供信息。
The influence of donor and recipient killer immunoglobulin-like receptor (KIR) genotype on the outcome of hematopoietic cell transplantation between human leukocyte antigen (HLA)-matched siblings was investigated. Transplants were divided into four groups according to the combination of group A and B KIR haplotypes in the transplant donor and recipient. Overall Survival of myeloid patients varied with KIR genotype combination. Best survival was associated with the donor lacking and the recipient having group B KIR haplotypes; poorest survival was associated with the donor having and the recipient lacking group B KIR haplotypes. The latter combination was also associated with increased relapse and acute graft-versus-host disease (GVHD). However, its detrimental effects were seen only for transplants where the recipient and donor were homozygous for the C1 KIR ligand and therefore lacked the C2 ligand. Presence of the Bw4 ligand was also associated with increased acute GVHD. In contrast presence of both KIR3DL1 and its cognate Bw4 ligand was associated with decreased nonrelapse mortality. Analysis of the KIR genes individually revealed KIR2DS3 as a protective factor for chronic GVHD. The results suggest how simple assessments of KIR genotype might inform the selection of donors for hematopoietic cell transplantation.