Why men's hearts break: Cardiovascular effects of sex steroids
Why men's hearts break: Cardiovascular effects of sex steroids
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DOI：
10.1016/j.ecl.2007.03.011
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发表时间：
2007-06-01
影响因子：
4.5
通讯作者：
McLaughlin, Mary Ann
中科院分区：
文献类型：
--
作者：
Choi, Brian G.;McLaughlin, Mary Ann
男性和女性的冠状动脉疾病 (CAD) 死亡率存在差异，因此人们猜测性类固醇的差异会导致风险增加。对照临床试验表明，雌激素替代疗法对某些女性没有心脏保护作用，最近的横断面研究将低睾酮水平与男性较高的 CAD 发病率联系起来。睾酮已被证明对胰岛素抵抗、肥胖、心肌、凝血、炎症、血管舒张和内皮功能有影响。性类固醇的不平衡会导致男性的心脏不良反应。
Coronary artery disease (CAD) mortality differs in men and women, leading to the speculation that differences in sex steroids contribute to risk. Controlled clinical trials have shown that estrogen replacement is not cardioprotective in certain women, and recent cross-sectional studies associate low testosterone with a greater incidence of CAD in men. Testosterone has demonstrated effects on insulin resistance, obesity, myocardium, coagulation, inflammation, vasodilation, and endothelial function. Imbalance of sex steroids contributes to adverse cardiac effects in men.