Expression of chemokines RANTES, MIP-1α and GRO-α correlates with inflammation in acute experimental autoimmune encephalomyelitis
Expression of chemokines RANTES, MIP-1α and GRO-α correlates with inflammation in acute experimental autoimmune encephalomyelitis
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DOI：
10.1159/000026333
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发表时间：
1998-05-01
影响因子：
2.4
通讯作者：
Ransohoff, RM
中科院分区：
文献类型：
--
作者：
Glabinski, AR;Tuohy, VK;Ransohoff, RM
实验性自身免疫性脑脊髓炎(EAE)是一种由研究人员发起的疾病，是常见的人类脱髓鞘疾病多发性硬化症的动物模型。这两种疾病的典型表现是中枢神经系统(CNS)血管周围和脑膜下的弥漫性袖带。近来研究表明，趋化因子在EAE的发病机制中起着不可或缺的作用。在本研究中，我们分析了三种趋化因子RANTES、MIP-1α和Gro-α在急性EAE发病时的基因表达，并将其表达与中枢神经系统炎症变化的强度相关联。我们发现，随着急性EAE症状的出现，所有三种趋化因子的表达都同时上调，并且趋化因子的表达与中枢神经系统的炎症强度有关。这种一致的关系支持趋化因子与白细胞在中枢神经系统实质中聚集有关的假说。
Experimental autoimmune encephalomyelitis (EAE) is an investigator-initiated disorder that serves as an animal model for the common human demyelinating disease multiple sclerosis. Both diseases are typified by disseminated perivascular and submeningeal cuffs in the central nervous system (CNS). It was shown recently that chemokines are integral to the pathogenesis of EAE. In the present study we analyzed the gene expression of three chemokines, RANTES, MIP-1 alpha and GRO-alpha, at the onset of acute EAE, and correlated that expression with the intensity of inflammatory changes in the CNS. We showed that all three chemokines are upregulated simultaneously with symptom onset of acute EAE, and that chemokine expression correlates with the intensity of inflammation in the CNS. This consistent relationship supports the hypothesis that chemokines are relevant to leukocyte accumulation in CNS parenchyma.