On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier.
On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier.
复制标题
咀嚼性持续的机械损害驱动稳态Th17细胞反应在口腔屏障处。
DOI：
10.1016/j.immuni.2016.12.010
复制
发表时间：
2017-01-17
期刊：
影响因子：
32.4
通讯作者：
Moutsopoulos NM
中科院分区：
文献类型：
--
作者：
Dutzan N;Abusleme L;Bridgeman H;Greenwell-Wild T;Zangerle-Murray T;Fife ME;Bouladoux N;Linley H;Brenchley L;Wemyss K;Calderon G;Hong BY;Break TJ;Bowdish DME;Lionakis MS;Jones SA;Trinchieri G;Diaz PI;Belkaid Y;Konkel JE;Moutsopoulos NM
在屏障位点运行的免疫监视网络通过局部组织信号进行调整，以确保有效的免疫。位点特异性共生细菌提供关键信号，确保宿主皮肤和肠道的防御。然而，口腔微生物组和组织特异性信号如何平衡牙龈（关键的口腔屏障）的免疫和调节仍然很少被探索。与皮肤和肠道相比，我们证明牙龈驻留 T 辅助细胞 17 (Th17) 细胞通过共生定植独立机制发育。咀嚼过程中发生的生理屏障损伤导致 Th17 细胞在牙龈处积聚。通过诱导上皮细胞产生白细胞介素 6 (IL-6)，定制效应 T 细胞功能，促进牙龈 Th17 细胞数量增加，从而产生生理机械损伤。这些数据强调了不同的组织特异性机制控制着 Th17 细胞反应的教育，并证明机械损伤有助于定义这一重要口腔屏障的免疫基调。独特的信号塑造口腔屏障处的 Th17 细胞网络 口腔屏障 Th17 细胞的发育独立于共生微生物定植 咀嚼造成的生理损伤促进口腔 Th17 细胞的产生 屏障损伤触发口腔 Th17 细胞介导的保护性免疫和炎症 调节牙龈（口腔屏障）免疫的信号仍不清楚。杜赞等人。表明口腔屏障 Th17 细胞是响应咀嚼而不是共生定植而被诱导的，将生理机械损伤识别为调节口腔屏障局部免疫和炎症的独特组织特异性线索。
Immuno-surveillance networks operating at barrier sites are tuned by local tissue cues to ensure effective immunity. Site-specific commensal bacteria provide key signals ensuring host defense in the skin and gut. However, how the oral microbiome and tissue-specific signals balance immunity and regulation at the gingiva, a key oral barrier, remains minimally explored. In contrast to the skin and gut, we demonstrate that gingiva-resident T helper 17 (Th17) cells developed via a commensal colonization-independent mechanism. Accumulation of Th17 cells at the gingiva was driven in response to the physiological barrier damage that occurs during mastication. Physiological mechanical damage, via induction of interleukin 6 (IL-6) from epithelial cells, tailored effector T cell function, promoting increases in gingival Th17 cell numbers. These data highlight that diverse tissue-specific mechanisms govern education of Th17 cell responses and demonstrate that mechanical damage helps define the immune tone of this important oral barrier. Distinct signals shape the Th17 cell network at the oral barrier Oral barrier Th17 cells develop independently of commensal microbe colonization Physiologic damage through mastication promotes the generation of oral Th17 cells Barrier damage triggers oral Th17-cell-mediated protective immunity and inflammation The signals regulating immunity at the gingiva, a key oral barrier, remain unclear. Dutzan et al. show that oral barrier Th17 cells are induced in response to mastication rather than commensal colonization, identifying physiologic mechanical damage as a unique tissue-specific cue conditioning local immunity and inflammation at the oral barrier.