Improved Reactive Oxygen Species Generation by Chiral Co3O4 Supraparticles under Electromagnetic Fields
Improved Reactive Oxygen Species Generation by Chiral Co3O4 Supraparticles under Electromagnetic Fields
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电磁场下手性 Co3O4 超粒子改善活性氧的产生
DOI：
10.1002/anie.202105675
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Kuang Hua
中科院分区：
文献类型：
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作者：
Wang Xiuxiu;Sun Maozhong;Qu Aihua;Wang Weiwei;Lu Meiru;Guo Xiao;Chen Chen;Hao Changlong;Xu Liguang;Xu Chuanlai;Kuang Hua
治疗血栓栓塞最常用的方法之一是使用溶栓药物激活纤溶蛋白酶。这种治疗的目的是启动纤维蛋白的溶解；然而，这种治疗方式有许多副作用。在此，我们制备了手性 Co3O4 超颗粒（SP），其在 550nm 处的 g 因子高达 0.02，具有顺磁性能，应用于电磁场（MF）下血栓栓塞的治疗。体外实验表明，d-SPs 在 MF 下 8 小时内降解血栓。与tol-SPs相比，d-SPs表现出更强的溶栓能力，在25天的观察中有效提高了血栓模型小鼠的存活率70%以上。机理研究结果表明，在MF下，d-SPs产生的活性氧（ROS）水平比l-SPs高1.5倍，这可能归因于手性诱导的自旋选择性效应。
One of the most common methods to treat thromboembolism is the use of thrombolytic drugs to activate fibrinolytic protease. The aim of this treatment was to initiate the lysis of fibrin; however, there are many side‐effects associated with this form of treatment. Herein, we fabricated chiral Co3O4supraparticles (SPs) with a g‐factor of up to 0.02 at 550 nm and paramagnetic performance applied in the treatment of thromboembolism under an electromagnetic field (MF). In vitro experiments showed thatd‐SPs degraded blood clot within 8 hours under MF. Compared tol‐SPs,d‐SPs exhibited much stronger thrombolytic ability and effectively enhanced the survival rate of thrombosis model mice more than 70 % in the 25 d of observation. The results of mechanism study showed that under MF, the level of reactive oxygen species (ROS) produced byd‐SPs were 1.5 times higher than that ofl‐SPs, which might be attributed to the chiral‐induced spin selectivity effects.