Zinc transporter 8 (ZnT8) and β cell function.
Zinc transporter 8 (ZnT8) and β cell function.
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锌转运蛋白8（Znt8）和β细胞功能。
DOI：
10.1016/j.tem.2014.03.008
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发表时间：
2014-08
影响因子：
10.9
通讯作者：
O'Brien, Richard M.
中科院分区：
文献类型：
--
作者：
Davidson, Howard W.;Wenzlau, Janet M.;O'Brien, Richard M.
人类胰腺β细胞具有异常高的锌含量。在β细胞中，锌浓度最高的是胰岛素分泌颗粒，锌从胰岛素分泌颗粒中与激素共同分泌。分泌颗粒对锌的摄取主要由锌转运蛋白8（ZnT8）介导，ZnT8是SLC30A8基因的产物。SLC30A8中几个单核苷酸多态性（SNP）的次要等位基因与2型糖尿病（T2D）风险降低相关，但保护作用的确切机制仍不确定。在这篇文章中，我们回顾了目前的知识ZnT8在维持β细胞中锌稳态的作用，其在葡萄糖代谢中的作用的基础上敲除小鼠的研究，以及目前的理论ZnT8功能和T2D之间的联系。
Human pancreatic β cells have exceptionally high zinc content. In β cells the highest zinc concentration is in insulin secretory granules, from which it is co-secreted with the hormone. Uptake of zinc into secretory granules is mainly mediated by zinc transporter 8 (ZnT8), the product of the SLC30A8 gene. The minor alleles of several single nucleotide polymorphisms (SNPs) in SLC30A8 are associated with decreased risk of type 2 diabetes (T2D), but the precise mechanisms underlying the protective effects remain uncertain. In this article we review current knowledge of the role of ZnT8 in maintaining zinc homeostasis in β cells, its role in glucose metabolism based on knockout mouse studies, and current theories regarding the link between ZnT8 function and T2D.
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影响因子：
30.8
作者：
Flannick, Jason;Thorleifsson, Gudmar;Beer, Nicola L.;Jacobs, Suzanne B. R.;Grarup, Niels;Burtt, Noel P.;Mahajan, Anubha;Fuchsberger, Christian;Atzmon, Gil;Benediktsson, Rafn;Blangero, John;Bowden, Don W.;Brandslund, Ivan;Brosnan, Julia;Burslem, Frank;Chambers, John;Cho, Yoon Shin;Christensen, Cramer;Douglas, Desiree A.;Duggirala, Ravindranath;Dymek, Zachary;Farjoun, Yossi;Fennell, Timothy;Fontanillas, Pierre;Forsen, Tom;Gabriel, Stacey;Glaser, Benjamin;Gudbjartsson, Daniel F.;Hanis, Craig;Hansen, Torben;Hreidarsson, Astradur B.;Hveem, Kristian;Ingelsson, Erik;Isomaa, Bo;Johansson, Stefan;Jorgensen, Torben;Jorgensen, Marit Eika;Kathiresan, Sekar;Kong, Augustine;Kooner, Jaspal;Kravic, Jasmina;Laakso, Markku;Lee, Jong-Young;Lind, Lars;Lindgren, Cecilia M.;Linneberg, Allan;Masson, Gisli;Meitinger, Thomas;Mohlke, Karen L.;Molven, Anders;Morris, Andrew P.;Potluri, Shobha;Rauramaa, Rainer;Ribel-Madsen, Rasmus;Richard, Ann-Marie;Rolph, Tim;Salomaa, Veikko;Segre, Ayellet V.;Skaerstrand, Hanna;Steinthorsdottir, Valgerdur;Stringham, Heather M.;Sulem, Patrick;Tai, E. Shyong;Teo, Yik Ying;Teslovich, Tanya;Thorsteinsdottir, Unnur;Trimmer, Jeff K.;Tuomi, Tiinamaija;Tuomilehto, Jaakko;Vaziri-Sani, Fariba;Voight, Benjamin F.;Wilson, James G.;Boehnke, Michael;McCarthy, Mark I.;Njolstad, Pal R.;Pedersen, Oluf;Groop, Leif;Cox, David R.;Stefansson, Kari;Altshuler, David
通讯作者：
Altshuler, David
影响因子：
--
作者：
Cauchi S;Nead KT;Choquet H;Horber F;Potoczna N;Balkau B;Marre M;Charpentier G;Froguel P;Meyre D
通讯作者：
Meyre D
影响因子：
2.7
作者：
Egefjord L;Jensen JL;Bang-Berthelsen CH;Petersen AB;Smidt K;Schmitz O;Karlsen AE;Pociot F;Chimienti F;Rungby J;Magnusson NE
通讯作者：
Magnusson NE
DOI：
10.1073/pnas.1200362109
发表时间：
2012-05-08
影响因子：
11.1
作者：
Hoch, Eitan;Lin, Wei;Sekler, Israel
通讯作者：
Sekler, Israel
影响因子：
4.1
作者：
DAVIDSON, HW;HUTTON, JC
通讯作者：
HUTTON, JC