O-(2-[18F]fluoroethyl)-l-tyrosine (18F-FET) uptake in mouse thymoma cells, and its biodistribution in mice and human volunteers
O-(2-[18F]fluoroethyl)-l-tyrosine (18F-FET) uptake in mouse thymoma cells, and its biodistribution in mice and human volunteers
复制标题
小鼠胸腺瘤细胞中的 O-(2-[18F]氟乙基)-l-酪氨酸 (18F-FET) 摄取及其在小鼠和人类志愿者中的生物分布
DOI：
10.1080/02841850600979055
复制
发表时间：
2006
期刊：
影响因子：
1.3
通讯作者：
H. Honda
中科院分区：
文献类型：
--
作者：
K. Abe;K. Hayashi;M. Sasaki;H. Koga;K. Kaneko;H. Sawamoto;K. Himuro;H. Honda
目的：研究O-(2-[18F]氟乙基)-L酪氨酸(18F-FET)在小鼠恶性胸腺瘤(EL4)中的摄取及其在小鼠和人体内的分布。材料和方法：首先，在体外实验中检测EL4细胞对18F-FET的摄取。其次，研究了EL4细胞和完全弗氏佐剂皮下注射后18F-FET在小鼠体内的摄取动力学及其在体内的分布。最后，研究了18F-FET在健康志愿者体内的摄取动力学和生物分布。结果：在体外实验中，18F-FET被广泛地掺入EL4细胞中。在一项动物研究中，18F-FET在正常器官中的累积在注射后30 分钟内达到峰值。在给药后60 分钟，肿瘤和炎性病变对肌肉组织的18F-FET摄取比值分别为2.18(2.00~2.29)和1.04(0.95~1.14)。在一项人体研究中，在注射18F-FET后60 分钟拍摄静态图像。肝脏(1.52，1.38-1.71)和肾脏(1.90，1.74-2.24)的平均标准摄取值(SUV)接近或略高于肌肉组织(1.19，0.99-1.33)。结论：18F-FET在胸腺瘤中的蓄积明显高于正常器官。18F-FET可作为一种有用的肿瘤显像剂。
Purpose: To evaluate O-(2-[18F]fluoroethyl)-l-tyrosine (18F-FET) uptake in mouse malignant thymoma (EL4), and its biodistribution in mice and humans. Material and Methods: First, 18F-FET uptake in EL4 cells was examined in an in vitro study. Second, the kinetics of 18F-FET uptake and its biodistribution were examined in mice after subcutaneous injection of EL4 cells and complete Freund's adjuvant. Finally, the kinetics of 18F-FET uptake and its biodistribution in healthy human volunteers were examined. Results: In an in vitro study, 18F-FET was extensively incorporated in EL4 cells. In an animal study, 18F-FET accumulation in normal organs peaked within 30 min postinjection. The mean ratios of 18F-FET uptake in tumors and in inflammatory lesions to that in muscle tissue at 60 min postadministration were 2.18 (range 2.00–2.29) and 1.04 (range 0.95–1.14), respectively. In a human study, static images were taken 60 min after 18F-FET administration. Mean standardized uptake values (SUVs) of the liver (1.52, range 1.38–1.71) and kidneys (1.90, range 1.74–2.24) were nearly equal or slightly higher than that of muscle tissue (1.19, range 0.99–1.33). Conclusion: This study demonstrates that 18F-FET accumulation in thymoma is significantly higher than in normal organs. 18F-FET could be a useful tracer for tumor imaging.
影响因子：
4.1
作者：
Nariai, T;Tanaka, Y;Ohno, K
通讯作者：
Ohno, K