Antifungal Activity of Micafungin in Serum
Antifungal Activity of Micafungin in Serum
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DOI：
10.1128/aac.01404-08
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发表时间：
2009-10-01
影响因子：
4.9
通讯作者：
Kanakura, Yuzuru
中科院分区：
文献类型：
--
作者：
Ishikawa, Jun;Maeda, Tetsuo;Kanakura, Yuzuru
我们采用纸片扩散法，以无血清和加血清米卡芬净标准曲线评价血清中米卡芬净的抗真菌活性。米卡芬净治疗患者的血清样本显示出足够的抗真菌活性，这与应用剂量和通过高效液相色谱法测量的米卡芬净实际浓度成比例。微量肉汤稀释法也证实了米卡芬净在血清中的抗真菌活性。
We have evaluated the antifungal activity of micafungin in serum by using the disk diffusion method with serum-free and serum-added micafungin standard curves. Serum samples from micafungin-treated patients have been shown to exhibit adequate antifungal activity, which was in proportion to both the applied dose and the actual concentration of micafungin measured by high-performance liquid chromatography. The antifungal activity of micafungin in serum was also confirmed with the broth microdilution method.