PERIPHERAL INJECTIONS OF VASOPRESSIN CONTROL BEHAVIOR BY WAY OF INTEROCEPTIVE SIGNALS FOR HYPERTENSION
PERIPHERAL INJECTIONS OF VASOPRESSIN CONTROL BEHAVIOR BY WAY OF INTEROCEPTIVE SIGNALS FOR HYPERTENSION
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DOI：
10.1016/0166-4328(85)90166-4
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发表时间：
1985-10-01
影响因子：
2.7
通讯作者：
LEMOAL, M
中科院分区：
文献类型：
--
作者：
BLUTHE, RM;DANTZER, R;LEMOAL, M
使用条件性味觉厌恶技术评估外周注射加压素的刺激特性。加压素诱导的条件性味觉厌恶被阻断之前暴露于加压素，但不是另一种厌恶剂，阿扑吗啡。先前暴露于行为等效剂量的另一种高血压药物，血管紧张素II，也阻断了条件性味觉厌恶引起的加压素，这种效果是完全互惠的，因为先前暴露于AVP阻断了血管紧张素II的厌恶作用。先前暴露于血管紧张素II所提供的保护不是由于内源性释放AVP，因为血管紧张素II的厌恶性质不被加压素的血管加压作用的特异性拮抗剂的给药所阻断。这些数据表明，内感受性线索，这是负责条件性味觉厌恶引起的加压素与高血压的行动，这种肽。
The stimulus properties of peripheral injections of vasopressin were assessed using conditioned taste aversion techniques. Conditioned taste aversion induced by vasopressin was blocked by prior exposure to vasopressin but not to another aversive agent, apomorphine. Prior exposure to behaviorally equivalent doses of another hypertensive agent, angiotensin II, blocked also conditioned taste aversion induced by vasopressin and this effect was fully reciprocal, since prior exposure to AVP blocked the aversive effect of angiotensin II. The protection offered by prior exposure to angiotensin II was not due to an endogenous release of AVP since the aversive properties of angiotensin II were not blocked by administration of a specific antagonist of the vasopressor effects of vasopressin. These data suggest that the interoceptive cues which are responsible for the conditioned taste aversion induced by vasopressin are related to the hypertensive action of this peptide.