Therapeutic external irradiation in women of reproductive age: risk estimation of hereditary effects
Therapeutic external irradiation in women of reproductive age: risk estimation of hereditary effects
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DOI：
10.1259/bjr/88840344
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发表时间：
2004-10-01
影响因子：
2.6
通讯作者：
Gourtsoyiannis, N
中科院分区：
文献类型：
--
作者：
Mazonakis, M;Damilakis, J;Gourtsoyiannis, N
育龄妇女受到电离辐射可能导致后代遗传疾病。本研究的目的是估计妇女治疗性外照射引起遗传效应的风险。用拟人体模模拟女性患者的放射治疗，测量了脑、乳腺和肺癌的放射治疗以及霍奇金病的卵巢剂量。这些恶性肿瘤是育龄妇女最常见的肿瘤之一。使用热释光剂量计进行剂量测量，所有暴露均采用6 MV X射线束。在脑癌、乳腺癌和肺癌的放射治疗中，卵巢的剂量分别为2-3 cGy、8-11 cGy和11-15 cGy，这取决于与主照射野的距离。治疗膈上和膈下霍奇金病的相应卵巢剂量分别为18-25 cGy和128-356 cGy。据估计，在膈上进行放射治疗的遗传性疾病的额外风险为（1-15）x10（-4）。盆腔照射导致遗传效应的风险增加（77-214）× 10（-4）。
Exposure of women of childbearing age to ionizing radiation may result in induction of genetic disorders in future generations. This study aims to estimate the risk of hereditary effects attributable to therapeutic external irradiation in women. An anthropomorphic phantom was used to simulate radiotherapy in female patients and ovarian dose was measured for irradiation of brain, breast and lung cancer, and for treatment of Hodgkin's disease. These malignancies are among the most common tumours presenting in women of reproductive age. Dose measurements were undertaken using thermoluminescent dosemeters and all exposures were made with 6 MV X-ray beams. The dose to ovaries was found to be 2-3 cGy, 8-11 cGy and 11-15 cGy depending on the distance from the primary irradiation field during radiotherapy of brain, breast and lung cancer, respectively. The corresponding ovarian dose resulting from treatment of supradiaphragmatic and infradiaphragmatic Hodgkin's disease was 18-25 cGy and 128-356 cGy, respectively. A small excess risk of genetic diseases of (1-15) x10(-4) was estimated for radiotherapy above the diaphragm. Pelvic irradiation resulted in an increased risk of hereditary effects of (77-214) x 10(-4).