Monitoring the community use of antibiotics in Italy within the National Action Plan on antimicrobial resistance
Monitoring the community use of antibiotics in Italy within the National Action Plan on antimicrobial resistance
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DOI：
10.1111/bcp.14461
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发表时间：
2020-09-07
影响因子：
3.4
通讯作者：
Gagliotti, Carlo
中科院分区：
文献类型：
--
作者：
Cangini, Agnese;Fortinguerra, Filomena;Gagliotti, Carlo
背景在意大利，抗生素的消耗量和细菌耐药性的流行率都高于其他欧洲国家。2017年，意大利通过了首个国家抗菌素耐药性行动计划(PNCAR)。作为对PNCAR的回应，已经发表了两份关于人类环境中抗生素使用的国家报告。这篇文章的目的是描述2013年至2018年意大利社区环境中抗生素的消费模式。方法采用不同数据来源，对社区药房发放的抗菌药物消费情况进行分析。消费量是根据限定的日剂量(DDD)、处方或使用率来衡量的。结果2018年，意大利每1000名居民每天的抗生素消耗量为16.1DDD。按地理区域划分的消费率为：北部12.7 DDD，中部16.9，南部20.4。在极端年龄组中的使用比在20岁至年龄段的人群中更大。冬季的消费量较高，流感综合征的发病率最高。在儿科人群中，处方使用率为1010张/1000名儿童，使用率为40.8%。结论本研究提供了有关意大利抗生素使用地域变异性的有用信息，以指导决策者根据PNCAR的建议，引入量身定制的干预措施，旨在促进人类更合理地使用抗生素，减少抗生素耐药性。
Background In Italy both the consumption of antibiotics and the prevalence of bacterial resistance are higher than in other European countries. In 2017, the first National Action Plan on Antimicrobial Resistance (PNCAR) was adopted in Italy. In response to the PNCAR two national reports on antibiotic use in the human setting have been published. This article's aim is to describe the pattern of antibiotic consumption in the community setting in Italy from 2013 to 2018. Methods To analyse the consumption for reimbursed antibiotics dispensed by community pharmacies different data sources were used. Consumption was measured in terms of defined daily dose (DDD), prescriptions or prevalence of use. Results In 2018, the consumption of antibiotics in Italy amounted to 16.1 DDD per 1000 inhabitants per day. The rates of consumption by geographical area were: 12.7 DDD in the north, 16.9 in the centre and 20.4 in the south. The use was greater in the extreme age groups than in the population aged from 20 to 64 years. The consumption was higher in winter season, with high peaks in the incidence of flu syndromes. In the paediatric population, a utilization rate of 1010 prescriptions per 1000 children, with a prevalence of use of 40.8%, was found. Conclusion The study provides useful information on the geographical variability of antibiotic use in Italy to guide decision makers in the introduction of tailored interventions, as suggested by PNCAR, aimed at promoting a more rational use of antibiotics for humans and reducing antimicrobial resistance.