Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer’s Disease Model Rats Induced by Aβ1–42
Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer’s Disease Model Rats Induced by Aβ1–42
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DOI：
10.1155/2016/6840432
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Li Hao
中科院分区：
文献类型：
--
作者：
Cao Yu;Jia Xingxing;Wei Yun;Liu Meixia;Liu Jiangang;Li Hao
Objective. Huannao Yicong Decoction (HYD, 还脑益聪方) has been shown to improve the learning and memory capabilities of.Alzheimer’s disease (AD) subjects.However, the underlying mechanism remains to be determined. Methods. Sixty Sprague-Dawley.rats were divided equally and randomly into five different groups including control, positive control, andHYDgranules of low dose,.medium dose, and high dose by daily gavage. The sham-treated rats were also given the same volume of sterile water by gavage..Twelve SD rats were treated with the same amount of physiological saline. Twelve weeks later, learning and memory capabilities,.A content of the right brain and the expression of glycogen synthase kinase-3 (GSK-3), total tau protein kinase (TTBK1), and.cyclin-dependent kinase-5 (CDK-5) were tested. Results. Our results showed that high dose HYD treatment significantly improved.the learning and memory capability of theADrats and decreased the expression of TTBK1, GSK-3, andCDK-5 in the hippocampal.CA1 region. Conclusions. HYD treatment for 12 weeks significantly improved spatial learning and memory and effectively inhibited.A deposition, likely via reducing tau protein kinase expression and thus tau hyperphosphorylation and inflammatory injury. Taken.together, these results suggest that HYD could be an effective treatment for AD.