Nickel-catalyzed borylation of arenes and indoles via C-H bond cleavage
Nickel-catalyzed borylation of arenes and indoles via C-H bond cleavage
复制标题
DOI：
10.1039/c5cc01378j
复制
发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Chatani, Naoto
中科院分区：
文献类型：
--
作者：
Furukawa, Takayuki;Tobisu, Mamoru;Chatani, Naoto
首次报道了镍催化的芳烃和吲哚的碳氢键硼化反应。N-杂环卡宾配体的使用对于有效的反应是必不可少的，其中N-环己基取代的衍生物是最佳的。该方法适用于2-硼吲哚的克级合成。
The first nickel-catalyzed method for the borylation of carbon-hydrogen bonds in arenes and indoles is described. The use of an N-heterocyclic carbene ligand is essential for an efficient reaction, with an N-cyclohexyl-substituted derivative being optimal. This method is readily applied to the gram scale synthesis of 2-borylindole.