Distinct sensory requirements for unimodal and cross-modal homeostatic synaptic plasticity.
Distinct sensory requirements for unimodal and cross-modal homeostatic synaptic plasticity.
复制标题
DOI：
10.1523/jneurosci.1424-12.2012
复制
发表时间：
2012-06-20
期刊：
影响因子：
--
通讯作者：
Lee HK
中科院分区：
文献类型：
--
作者：
He K;Petrus E;Gammon N;Lee HK
Loss of a sensory modality elicits both unimodal changes in the deprived cortex and cross-modal alterations in the remaining sensory systems. Unimodal changes are proposed to recruit the deprived cortex for processing the remaining senses, while cross-modal changes are thought to refine processing of spared senses. Hence coordinated unimodal and cross-modal changes are likely beneficial. Despite this expectation, we report in mice that losing behaviorally relevant patterned vision is sufficient to trigger cross-modal synaptic changes in the primary somatosensory cortex barrel fields (S1BFs), but is insufficient to drive unimodal synaptic plasticity in visual cortex (V1), which requires a complete loss of visual activity. In addition, cross-modal changes depend on whisker inputs. Our results demonstrate that unimodal and cross-modal synaptic plasticity occur independently of each other and rely on distinct sensory requirements.
