Neurodevelopmental vulnerability to psychosis: developmentally-based methods enable detection of early life inhibitory control deficits that predict psychotic-like experiences at the transition to adolescence.
Neurodevelopmental vulnerability to psychosis: developmentally-based methods enable detection of early life inhibitory control deficits that predict psychotic-like experiences at the transition to adolescence.
复制标题
神经发育对精神病的脆弱性：基于发育的方法能够检测早期生命的抑制控制缺陷，从而预测向青春期过渡时的类似精神病的经历。
DOI：
10.1017/s003329172300171x
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发表时间：
2023
影响因子：
6.9
通讯作者：
Mittal,VijayA
中科院分区：
文献类型：
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作者：
Zarubin,VanessaC;Damme,KatherineSF;Vargas,Teresa;Osborne,KJuston;Norton,ElizabethS;Briggs-Gowan,Margaret;Allen,NorrinaB;Wakschlag,Laurie;Mittal,VijayA
背景抑制性控制在儿童早期发展，非典型发展可能是后期精神病发展风险的可测量标志。此外，抑制控制可能是干预的目标。MethodsBehavioral performance on a developmentally appropriate Go/No-Go task including a frustration manipulation completed by children age 3-5 years（幼儿期; n = 107）进行了检查，与精神病样经验（PLEs;“tween '; 9-12岁），在长期随访（青春期前; 8-11岁）时自我报告的内化症状和外化症状。ERP N200振幅的一个子集，这些儿童（n = 34）的电生理数据在task.ResultsChildren在No-Go试验较低的准确性相比，在儿童早期的Go试验（F（1，101）= 3.976，p = 0.049），证明较高的PLEs在过渡到青春期4-9年后，反映了抑制控制的特定缺陷。未观察到与内化或外化症状的关联。挫折处理过程中准确性的降低预测了更高的内化，F（2，202）= 5.618，p = 0.004，和外化症状，F（2，202）= 4.663，p = 0.010。较小的N200振幅上观察到的那些具有较高的PLEs，F（1，101）= 6.075，P = 0.020的No-Go试验，没有关系观察到内化或外化symptoms.ConclusionsLong-term后续行动表明，第一次在抑制控制行为和电生理的具体赤字，为个人谁后来报告更多的PLEs。挫折诱导下的任务表现下降，表明风险的内化和外化症状。这些研究结果表明，精神病的病理生理机制是相关的，并在儿童早期的歧视，并进一步提出了一个可识别的和潜在的可修改的早期干预目标。
BackgroundInhibitory control develops in early childhood, and atypical development may be a measurable marker of risk for the later development of psychosis. Additionally, inhibitory control may be a target for intervention.MethodsBehavioral performance on a developmentally appropriate Go/No-Go task including a frustration manipulation completed by children ages 3–5 years (early childhood; n = 107) was examined in relation to psychotic-like experiences (PLEs; ‘tween’; ages 9–12), internalizing symptoms, and externalizing symptoms self-reported at long-term follow-up (pre-adolescence; ages 8–11). ERP N200 amplitude for a subset of these children (n = 34) with electrophysiological data during the task was examined as an index of inhibitory control.ResultsChildren with lower accuracy on No-Go trials compared to Go trials in early childhood (F(1,101) = 3.976, p = 0.049), evidenced higher PLEs at the transition to adolescence 4–9 years later, reflecting a specific deficit in inhibitory control. No association was observed with internalizing or externalizing symptoms. Decreased accuracy during the frustration manipulation predicted higher internalizing, F(2,202) = 5.618, p = 0.004, and externalizing symptoms, F(2,202) = 4.663, p = 0.010. Smaller N200 amplitudes were observed on No-Go trials for those with higher PLEs, F(1,101) = 6.075, p = 0.020; no relationship was observed for internalizing or externalizing symptoms.ConclusionsLong-term follow-up demonstrates for the first time a specific deficit in inhibitory control behaviorally and electrophysiology, for individuals who later report more PLEs. Decreases in task performance under frustration induction indicated risk for internalizing and externalizing symptoms. These findings suggest that pathophysiological mechanisms for psychosis are relevant and discriminable in early childhood, and further, suggest an identifiable and potentially modifiable target for early intervention.