Interaction between amygdala and neocortical inputs in the perirhinal cortex.
Interaction between amygdala and neocortical inputs in the perirhinal cortex.
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杏仁核和鼻周皮质新皮质输入之间的相互作用。
DOI：
10.1152/jn.00260.2005
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Pare,Denis
中科院分区：
文献类型：
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作者：
Pelletier,JoeGuillaume;Apergis-Schoute,John;Pare,Denis
鼻腔皮质在高阶知觉/记忆功能中起着关键作用，并构成了进出海马的脉冲交通的主要途径。然而，以前的工作表明，新皮层刺激，激活了大部分的嗅周神经元不能放电内嗅细胞。在寻找机制，可能有利于冲动从新皮层转移到内嗅皮层，我们已经研究了异氟烷麻醉动物的外侧杏仁核（LA）的激活所产生的兴奋性的变化。LA刺激激活了大部分的内嗅神经元和内嗅神经元。然而，条件LA刺激并没有增加新皮层输入激活内嗅细胞的能力，即使这样的配对产生显着增加neocortically诱发的场电位和顺向发射在嗅周皮层。此外，增加neocortically诱发的嗅周场电位和单位的反应持续时，条件LA休克被替换为另一个新皮层刺激在相同或不同的网站作为测试冲击。这perirhinal配对脉冲促进（PPF）是最大的刺激间隔为100 ms。细胞内记录的perirhinal神经元显示，PPF通常与抑制和兴奋之间的平衡的快速转变，导致perirhinal反应的整体增加。这些研究结果的意义的嗅周皮质的作用进行了讨论。
The rhinal cortices play a critical role in high-order perceptual/mnemonic functions and constitute the main route for impulse traffic to and from the hippocampus. However, previous work has revealed that neocortical stimuli that activate a large proportion of perirhinal neurons are unable to discharge entorhinal cells. In search of mechanisms that might facilitate impulse transfer from the neocortex to the entorhinal cortex, we have examined changes in excitability produced by activation of the lateral amygdala (LA) in isoflurane-anesthetized animals. LA stimulation activated a large proportion of peri- and entorhinal neurons. However, conditioning LA stimuli did not increase the ability of neocortical inputs to activate entorhinal cells even though such pairing produced marked increases in neocortically evoked field potentials and orthodromic firing in the perirhinal cortex. Moreover, increased neocortically evoked perirhinal field potentials and unit responses persisted when the conditioning LA shock was replaced by another neocortical stimulus at the same or at a different site as the testing shock. This perirhinal paired-pulse facilitation (PPF) was maximal with interstimulus intervals of ∼100 ms. Intracellular recordings of perirhinal neurons revealed that the PPF was generally associated with a rapid shift in the balance between inhibition and excitation, leading to an overall increase in perirhinal responsiveness. The significance of these findings for the role of the perirhinal cortex is discussed.