Inference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach.
Inference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach.
复制标题
基于原核基因组组织的结核分枝杆菌中蛋白质功能和蛋白质链接的推断：一种合并的计算方法。
DOI：
10.1186/gb-2003-4-9-r59
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发表时间：
2003
期刊：
影响因子：
12.3
通讯作者：
Eisenberg, David
中科院分区：
文献类型：
--
作者：
Strong, Michael;Mallick, Parag;Pellegrini, Matteo;Thompson, Michael J;Eisenberg, David
以结核分枝杆菌基因组为研究对象，通过比较基因组同一方向上基因间的核苷酸距离来推断可能属于同一操纵子的基因，并将该方法与Rosetta Stone、Phylogenetic Profile和保守的Gene Neighbor计算方法相结合，用于蛋白质功能的推断。结核分枝杆菌的基因组进行了分析，使用最近开发的计算方法来推断蛋白质功能和蛋白质连接。我们评估并采用了一种方法来推断可能属于同一操纵子的基因，根据相同基因组方向上基因之间的核苷酸距离来判断，并将该方法与Rosetta Stone，Phylogenetic Profile和保守的Gene Neighbor计算方法相结合，用于推断蛋白质功能。
The genome of Mycobacterium tuberculosis was used to evaluate and employ a method to infer genes likely to belong to the same operon, as judged by the nucleotide distance between genes in the same genomic orientation, and this method was combined with those of the Rosetta Stone, Phylogenetic Profile and conserved Gene Neighbor computational methods for the inference of protein function. The genome of Mycobacterium tuberculosis was analyzed using recently developed computational approaches to infer protein function and protein linkages. We evaluated and employed a method to infer genes likely to belong to the same operon, as judged by the nucleotide distance between genes in the same genomic orientation, and combined this method with those of the Rosetta Stone, Phylogenetic Profile and conserved Gene Neighbor computational methods for the inference of protein function.