DIFFERENTIAL EXPRESSION OF FOS PROTEIN IN THE BRAIN OF FEMALE MICE DEPENDENT ON PUP SENSORY CUES AND MATERNAL EXPERIENCE
DIFFERENTIAL EXPRESSION OF FOS PROTEIN IN THE BRAIN OF FEMALE MICE DEPENDENT ON PUP SENSORY CUES AND MATERNAL EXPERIENCE
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DOI：
10.1037/0735-7044.108.1.113
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发表时间：
1994-02-01
影响因子：
1.9
通讯作者：
KEVERNE, EB
中科院分区：
文献类型：
--
作者：
CALAMANDREI, G;KEVERNE, EB
Fos蛋白的免疫反应后30分钟的感觉和行为的经验与寄养幼鼠在不同的大脑区域的未生育的雌性Balb/c小鼠谁是完整的，卵巢切除，或选择性地耗尽嗅球去甲肾上腺素。Fos的表达进行了研究，在完整的未经产的雌性小鼠进行远端暴露于幼崽的感觉线索。与幼犬的行为相互作用增加Fos免疫反应性的嗅觉区（前嗅核，梨状皮质，皮质杏仁核，内嗅皮质），以及在内侧视前区，无论女性是否完整或卵巢切除。去甲肾上腺素耗尽的嗅球阻止Fos诱导在初级嗅觉区，但不是在内侧视前区，而远端暴露于小狗线索增强Fos表达在嗅觉区，但不是在内侧视前区。
Immunoreactivity for Fos protein following 30 min of sensory and behavioral experience with foster pups was measured in different brain areas of nulliparous female Balb/c mice who were intact, ovariectomized, or selectively depleted of olfactory bulb noradrenaline. Fos expression was also investigated in intact nulliparous female mice undergoing distal exposure to pup sensory cues. Behavioral interaction with pups increased Fos immunoreactivity in the olfactory areas (anterior olfactory nucleus, piriform cortex, corticomedial amygdala, and entorhinal cortex) as well as in the medial preoptic area, and this occurred regardless of whether females were intact or ovariectomized. Noradrenaline depletion of the olfactory bulb prevented Fos induction in primary olfactory areas, but not in the medial preoptic area, whereas distal exposure to pup cues enhanced Fos expression in the olfactory areas but not in the medial preoptic area.