General and Selective Head-to-Head Dimerization of Terminal Alkynes Proceeding via Hydropalladation Pathway
General and Selective Head-to-Head Dimerization of Terminal Alkynes Proceeding via Hydropalladation Pathway
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DOI：
10.1021/ol3010936
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发表时间：
2012-06-01
期刊：
影响因子：
5.2
通讯作者：
Gevorgyan, Vladimir
中科院分区：
文献类型：
--
作者：
Jahier, Claire;Zatolochnaya, Olga V.;Gevorgyan, Vladimir
介绍了钯催化的末端乙炔头对头二聚化反应。这种方法可以有效地合成各种1,4-烯作为单一的E立体异构体。计算研究表明，这种二聚化反应是通过水钯化途径进行的。
A general highly regio- and stereoselective palladium-catalyzed head-to-head dimerization reaction of terminal acetylenes is presented. This methodology allows for the efficient synthesis of a variety of 1,4-enynes as single E stereoisomers. Computational studies reveal that this dimerization reaction proceeds via the hydropalladation pathway.