A systems- and signal-oriented approach to intracellular dynamics.
A systems- and signal-oriented approach to intracellular dynamics.
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一种面向系统和信号的细胞内动力学方法。
DOI：
10.1042/bst0330507
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Cho,K-H
中科院分区：
文献类型：
--
作者：
Wolkenhauer,O;Sreenath,SN;Wellstead,P;Ullah,M;Cho,K-H
对调节的数学理解，特别是反馈的作用，对物理科学和技术的进步至关重要。在这篇文章中，系统生物学提供的框架被用来论证分子生物学也是如此。特别是，并使用基本的模块化方法的数学建模，这是标准的控制理论，一组动态模型开发的一些说明性的细胞信号传导过程。这些模型，最近的实验证据的支持下，被用来争辩说，控制理论的方法，在细胞内信号反馈的机制是中央，以进一步了解分子通信。作为一个具体的例子，MAPK（丝裂原活化蛋白激酶）信号通路被用来显示如何在信号传导过程中的潜在反馈机制，可以在模拟环境中进行调查。多年来，这种“如果”建模/模拟研究一直是物理科学研究的一个组成部分。使用控制系统分析的工具，体现在系统生物学的学科，类似的预测建模/模拟研究，现在在细胞信号转导研究的成果。
A mathematical understanding of regulation, and, in particular, the role of feedback, has been central to the advance of the physical sciences and technology. In this article, the framework provided by systems biology is used to argue that the same can be true for molecular biology. In particular, and using basic modular methods of mathematical modelling which are standard in control theory, a set of dynamic models is developed for some illustrative cell signalling processes. These models, supported by recent experimental evidence, are used to argue that a control theoretical approach to the mechanisms of feedback in intracellular signalling is central to furthering our understanding of molecular communication. As a specific example, a MAPK (mitogen-activated protein kinase) signalling pathway is used to show how potential feedback mechanisms in the signalling process can be investigated in a simulated environment. Such ‘what if’ modelling/simulation studies have been an integral part of physical science research for many years. Using tools of control systems analysis, as embodied in the disciplines of systems biology, similar predictive modelling/simulation studies are now bearing fruit in cell signalling research.