Bioactive TiNbSn alloy prepared by anodization in sulfuric acid electrolytes
Bioactive TiNbSn alloy prepared by anodization in sulfuric acid electrolytes
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DOI：
10.1016/j.msec.2019.01.033
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发表时间：
2019-05-01
影响因子：
7.9
通讯作者：
Hanada, S.
中科院分区：
文献类型：
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作者：
Masahashi, N.;Mori, Y.;Hanada, S.
研究了在硫酸电解质中制备的低杨氏模量阳极化近β TiNbSn合金的生物活性，探讨了其骨整合机制，重点研究了阳极氧化物的作用。羟基磷灰石（Hydroxyapatite， HA）在Hank’s溶液中浸泡后在阳极氧化物表面析出，随着电解液硫酸浓度的增加，析出速度加快。羟基磷灰石是在阳极氧化后的氧化物表面形成的，无需后续退火或热水（HW）处理。这一结果不同于先前的一项研究，该研究使用在醋酸电解质中制备的阳极化的TiNbSn合金，需要后续的HW处理。研究发现，在硫酸电解液中阳极氧化的氧化物含有大量的内部孔隙，是高结晶的厚TiO2，而在醋酸电解液中阳极氧化的氧化物是低结晶的薄TiO2，含有少量的孔隙。优选阳极化的TiNbSn合金，以保持合金的低杨氏模量，并消除后续处理以提高杨氏模量。在一系列研究的基础上，提出了合理评价现有阳极氧化物生物活性的模型。由此可见，硫酸电解质有利于HA的形成和较低的杨氏模量，其生物活性归因于阳极TiO2有利于骨成分的掺入。
The bioactivity of anodized near-beta TiNbSn alloy with low Young's modulus prepared in sulfuric acid electrolytes was examined to explore the osseointegration mechanism with a focus on the role of anodic oxide. Hydroxyapatite (HA) precipitated on the surface of anodic oxide following immersion in Hank's solution, and precipitation accelerated with increase in the sulfuric acid concentration of the electrolyte. HA is formed on the surface of as-anodized oxide without subsequent annealing or hot water (HW) treatment. This outcome differs from that of a previous study using anodized TiNbSn alloy prepared in acetic acid electrolytes requiting for subsequent HW treatment. It was found that the oxide anodized in sulfuric acid electrolyte contains a large amount of internal pores and is highly crystallized thick TiO2, whereas the same prepared in the acetic acid electrolyte is low crystalline thin TiO2 containing a small amount of pores. The present anodized TiNbSn alloy is preferred for maintaining the low Young's modulus of the alloy and eliminating the subsequent treatment to increase the Young's modulus. A model to rationalize the bioactivity of the present anodic oxide is proposed based on the series of studies. It is concluded that the sulfuric acid electrolyte is favorable for both HA formation and low Young's modulus, and the bioactivity is attributed to the anodic TiO2 that facilitates incorporation of bone ingredients.