Musashi-1 expression in postnatal mouse olfactory epithelium
Musashi-1 expression in postnatal mouse olfactory epithelium
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DOI：
10.1097/wnr.0b013e3280bef7e2
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发表时间：
2007-05
期刊：
影响因子：
1.7
通讯作者：
Kenta Watanabe;K. Kondo;N. Takeuchi;H. Okano;T. Yamasoba
中科院分区：
文献类型：
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作者：
Kenta Watanabe;K. Kondo;N. Takeuchi;H. Okano;T. Yamasoba
我们研究了神经干细胞和前体细胞的分子标记物Musashi-1在小鼠嗅上皮中的分布与年龄相关的变化，从1天到16个月的年龄，使用免疫组织化学。我们还比较了Musashi-1与嗅觉标记蛋白生长相关蛋白43和Notch-1的分布模式。Musashi-1在球状基底细胞层和生长相关蛋白43阳性层的下部表达，免疫反应性随着年龄的增长而降低。Notch-1仅在出生后早期观察到。这些发现与球状基底细胞是增殖的嗅觉前体细胞以及它们产生新神经元的能力随着年龄的增长而下降的事实是一致的。
We investigated the age-related change in the distribution of a molecular marker for neural stem and precursor cells, Musashi-1, in the olfactory epithelium of mice from 1 day up to 16 months of age using immunohistochemistry. We also compared the distribution pattern of Musashi-1 with that of growth-associated protein 43, the olfactory marker protein, and Notch-1. Musashi-1 was expressed in the globose basal cell layer and the lower part of the growth-associated protein 43-positive layer, with immunoreactivity decreasing with aging. Notch-1 was observed only in the early postnatal period. These findings are consistent with the fact that globose basal cells are proliferating olfactory precursor cells and that their ability to generate new neurons decreases with aging.