Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.
Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.
复制标题
多重耐药基因在肝癌发生和大鼠肝脏再生中的表达。
作者：
S. Thorgeirsson;B. E. Huber;S. Sorrell;A. Fojo;I. Pastan;M. Gottesman
从再生大鼠肝脏中分离的癌前和肿瘤性肝结节和肝细胞已被证明对广泛的致癌剂具有抗性。这一现象是通过测量多药耐药（mdr）基因在正常肝细胞、癌前和肿瘤结节以及再生肝中的表达来研究的。mdr基因（编码P-糖蛋白）的信使RNA水平在癌前病变和肿瘤病变中均升高。部分肝切除后24 - 72小时，再生肝中mdr基因的表达也达到高水平。这些结果表明，mdr基因的表达可以在肝脏中调节，并可能是致癌物引发的肝细胞和再生肝细胞的多药耐药表型的一部分。
Preneoplastic and neoplastic liver nodules and hepatocytes isolated from regenerating rat liver have been shown to be resistant to a broad range of carcinogenic agents. This phenomenon was studied by measuring the expression of the multidrug-resistant (mdr) gene in normal liver cells and in preneoplastic and neoplastic nodules and regenerating liver. Levels of messenger RNA for the mdr gene, which encodes P-glycoprotein, were elevated in both preneoplastic and neoplastic lesions. Expression of the mdr gene also reached high levels in regenerating rat liver 24 to 72 hours after partial hepatectomy. These results show that the expression of the mdr gene can be regulated in liver and is likely to be responsible for part of the multidrug-resistance phenotype of carcinogen-initiated hepatocytes and regenerating liver cells.
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影响因子：
3.7
作者：
Okuda H;Kuwahara R;Matsuzaki S;Miyata S;Kumamoto N;Hattori T;Shimizu S;Yamada K;Kawamoto K;Hashimoto R;Takeda M;Katayama T;Tohyama M
通讯作者：
Tohyama M
DOI：
10.1073/pnas.83.12.4538
发表时间：
1986-06-01
影响因子：
11.1
作者：
RONINSON, IB;CHIN, JE;PASTAN, I
通讯作者：
PASTAN, I
DOI：
10.1016/s0021-9258(18)61633-3
发表时间：
1987-02
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
M. Cornwell;I. Pastan;M. Gottesman
通讯作者：
M. Cornwell;I. Pastan;M. Gottesman
哺乳动物细胞中与多药耐药性相关的基因的扩增和表达。
DOI：
10.1126/science.2421411
发表时间：
1986
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Scotto,KW;Biedler,JL;Melera,PW
通讯作者：
Melera,PW