Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring.
Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring.
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DOI：
10.1016/j.tetlet.2012.05.156
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发表时间：
2012-08-08
影响因子：
1.8
通讯作者：
Cichewicz, Robert H.
中科院分区：
文献类型：
--
作者：
Gerea, Alexandra L.;Branscum, Katie M.;King, Jarrod B.;You, Jianlan;Powell, Douglas R.;Miller, Andrew N.;Spear, John R.;Cichewicz, Robert H.
从一个复杂的微生物垫上获得了真菌分离物的集合，这个微生物垫占据了一个富含铁的淡水泉水，该泉水流入了美国科罗拉多州金色的Clear Creek。两个真菌分离物，一个球孢菌科(可能是内生孢霉菌)和一株具有生物活性的次生代谢物进行了研究。共分离得到6个新化合物，分别为清香醇A-E(5，6，10-12)和二磺酸甘油酯(7)，并对其结构进行了鉴定。二磺酸甘油对耐甲氧西林金黄色葡萄球菌有一定的抗菌活性，而透明质醇C对白色念珠菌生物被膜的形成有较弱的抑制作用。
A collection of fungal isolates was obtained from a complex microbial mat, which occupied an iron-rich freshwater spring that feeds into Clear Creek, Golden, Colorado, USA. Two of the fungal isolates, a Glomeromycete (possible Entrophospora sp.) and a Dothideomycete (possible Phaeosphaeria sp.), were investigated for bioactive secondary metabolites. In total, six new compounds consisting of clearanols A–E (5, 6, 10–12) and disulochrin (7) were purified and their structures were determined. Disulochrin exhibited modest antibacterial activity against methicillin-resistant Staphylococcus aureus, whereas clearanol C showed weak inhibitory activity against Candida albicans biofilm formation.
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影响因子：
4.4
作者：
Feazel, Leah M.;Spear, John R.;Pace, Norman R.
通讯作者：
Pace, Norman R.
影响因子：
5.1
作者：
Wang X;You J;King JB;Powell DR;Cichewicz RH
通讯作者：
Cichewicz RH
影响因子：
5.1
作者：
Henrikson JC;Ellis TK;King JB;Cichewicz RH
通讯作者：
Cichewicz RH
影响因子：
14.8
作者：
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通讯作者：
Dorrestein, Pieter C.
影响因子：
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作者：
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通讯作者：
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