Free radical polymers with tunable and selective bio- and chemical degradability.
Free radical polymers with tunable and selective bio- and chemical degradability.
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DOI：
10.1021/ja903245p
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发表时间：
2009-07-22
影响因子：
15
通讯作者：
Hawker, Craig J.
中科院分区：
文献类型：
--
作者：
Paulusse, Jos M. J.;Amir, Roey J.;Evans, Richard A.;Hawker, Craig J.
已经开发了一种通用的合成策略，其使得能够将可裂解的官能团（即酯、硫酯和二硫化物）容易地掺入到基于乙烯基的聚合物的碳-碳主链中。通过合成新的环状单体，RAFT介导的自由基开环共聚与传统的乙烯基单体，如甲基丙烯酸甲酯，N，N-二甲基氨基乙基甲基丙烯酸酯和2-羟乙基甲基丙烯酸酯导致引入到这些广泛使用的乙烯基共聚物系统的可控降解性。该策略的另一个益处是通过掺入含有不同官能团的环状单体（例如酯、硫酯、二硫化物和甲硅烷基醚单元）而获得的固有多功能性，所述环状单体允许在碱性/酸性、还原性或酶促条件下降解。通过将多个正交环状单体整合到线性共聚物主链中，获得了具有可编程降解曲线的明确定义的系统，其允许乙烯基聚合物主链的可调、选择性和逐步降解。
A versatile synthetic strategy has been developed which enables the facile incorporation of cleavable functional groups, i.e. esters, thioesters and disulfides, into the carbon-carbon backbone of vinyl-based polymers. Through the synthesis of novel cyclic monomers, RAFT-mediated radical ring-opening copolymerizations with traditional vinyl monomers such as methyl methacrylate, N,N-dimethylaminoethyl methacrylate and 2-hydroxyethyl methacrylate leads to the introduction of controlled degradability into these widely used vinyl copolymer systems. An additional benefit of this strategy is the inherent versatility available through the incorporation of cyclic monomers containing diverse functional groups such as esters, thioesters, disulfides and silyl ether units that allow degradation under basic/acidic, reductive or enzymatic conditions. By integrating multiple, orthogonal cyclic monomers into linear copolymer backbones, well-defined systems with programmable degradation profiles are obtained which allows for tunable, selective and step-wise degradation of the vinyl polymer backbones.
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影响因子：
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作者：
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