Different Hippocampus Functional Connectivity Patterns in Healthy Young Adults with Mutations of APP/Presenilin-1/2 and APOEε4.
Different Hippocampus Functional Connectivity Patterns in Healthy Young Adults with Mutations of APP/Presenilin-1/2 and APOEε4.
复制标题
APP/Presenilin-1/2 和 APOEμ4 突变的健康年轻人的不同海马功能连接模式
DOI：
10.1007/s12035-017-0540-4
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发表时间：
2017
影响因子：
5.1
通讯作者：
Long Jiang Zhang
中科院分区：
文献类型：
--
作者：
Li Juan Zheng;Yun Yan Su;Yun Fei Wang;U. Joseph Schoepf;Akos Varga-Szemes;Jonathan Pannell;Xue Liang;Gang Zheng;Guang Ming Lu;Gui Fen Yang;Long Jiang Zhang
本研究旨在探讨年轻、健康的APP和/或早老素-1/2突变携带者和APOE ε4受试者中基于大脑皮层的功能连接模式。78名健康年轻人（33名男性，平均年龄24.0 ± 2.2岁; 18名APP和/或早老素1/2突变携带者[APP/早老素1/2组]，30名APOE ε4受试者[APOE ε4组]，30名无上述基因的受试者[对照组]）接受了静息态功能MR成像和神经心理学评估。比较三组间双侧海马功能连接模式。然后提取具有统计学差异的脑区，并对脑区的Z值与神经心理学结果进行相关分析。与对照组相比，APOE ε4组和APP/Presenilin-1/2组大鼠双侧大脑皮层种子区内侧前额叶皮层和楔前叶的功能连接增强。与对照组相比，APOE ε4组从双侧海马到左侧颞中回的功能连接增强。此外，与APP/Presenilin-1/2组相比，APOE ε4组的右侧海马-左侧颞中回的功能连接也明显增加。所有受试者及APOE ε4组的右侧海马-左侧颞中回的Z值与各种神经心理学结果相关。携带APOE ε4和APP/Presenilin-1/2的健康青年人表现出不同的海马功能连接模式，这可能是阿尔茨海默病中基因调节的认知功能障碍的不同机制的基础。
This study aims to explore the hippocampus-based functional connectivity patterns in young, healthy APP and/or presenilin-1/2 mutation carriers and APOE ε4 subjects. Seventy-eight healthy young adults (33 male, mean age 24.0 ± 2.2 years; 18 APP and/or presenilin1/2 mutation carriers [APP/presenilin-1/2 group], 30 APOE ε4 subjects [APOE ε4 group], and 30 subjects without the above-mentioned genes [control group]) underwent resting-state functional MR imaging and neuropsychological assessments. Bilateral hippocampus functional connectivity patterns were compared among three groups. The brain regions with statistical differences were then extracted, and correlation analyses were performed between Z values of the brain regions and neuropsychological results. Compared with control group, both APOE ε4 group and APP/presenilin-1/2 group showed increased functional connectivity in medial prefrontal cortex and precuneus for the seeds of bilateral hippocampi. The APOE ε4 group displayed increased functional connectivity from bilateral hippocampi to the left middle temporal gyrus compared with the control group. Moreover, compared with the APP/presenilin-1/2 group, the APOE ε4 group also had markedly increased functional connectivity in right hippocampus-left middle temporal gyrus. The Z values of right hippocampus-left middle temporal gyrus correlated with various neuropsychological results across all the subjects, as well as in APOE ε4 group. Young healthy adults carrying APOE ε4 and APP/presenilin-1/2 displayed different hippocampus functional connectivity patterns, which may underlie the discrepant mechanisms of gene-modulated cognitive dysfunction in Alzheimer’s disease.