Correlates of markers of oxidative status in the general population
Correlates of markers of oxidative status in the general population
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DOI：
10.1093/aje/154.4.348
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发表时间：
2001-08-15
影响因子：
5
通讯作者：
Armstrong, D
中科院分区：
文献类型：
--
作者：
Trevisan, M;Browne, R;Armstrong, D
氧化应激与包括心血管疾病在内的许多慢性疾病的病因学有关。然而，有限的信息存在的因素，可能会影响一般人群中的氧化状态。在纽约西部两个县的人群中随机抽样，几种氧化状态标志物的水平（即，硫代巴比妥酸反应物质、红细胞谷胱甘肽和谷胱甘肽过氧化物酶）。这项研究共包括894名男子和903名妇女，年龄在35-79岁之间（1996-1999年）。此外，还测量了一些社会人口统计学和生活方式特征以及心血管疾病风险因素。年龄、葡萄糖代谢标志物（例如，血浆葡萄糖水平）和胰岛素抵抗（例如，血清甘油三酯、高密度脂蛋白胆固醇、体重指数）和妇女绝经后状态与氧化应激增加和抗氧化潜力降低相关。氧化状态和抗氧化潜力似乎与许多主要的心血管疾病风险因素显著相关;其中大多数与葡萄糖和胰岛素代谢异常有关。
Oxidative stress has been implicated in the etiology of many chronic diseases, including cardiovascular disease. However, limited information exists on the factors that may influence oxidative status in the general population. In a random sample of the population of two counties in western New York, levels of several markers of oxidative status (i.e., thiobarbituric acid-reactive substances, erythrocyte glutathione, and glutathione peroxidase) were determined. A total of 894 men and 903 women aged 35-79 years were included in the study (1996-1999). In addition, a number of sociodemographic and lifestyle characteristics and cardiovascular disease risk factors were measured. Age, markers of glucose metabolism (e.g., plasma glucose level) and insulin resistance (e.g., serum triglycerides, high density lipoprotein cholesterol, body mass index), and postmenopausal status in women were associated with increased oxidative stress and reduced antioxidant potentials. Oxidative status and antioxidant potentials appear to be significantly associated with a number of major cardiovascular disease risk factors; most of them are linked to abnormalities in glucose and insulin metabolism.