The combined use of bioresorbable membranes and xenografts or autografts in the treatment of bone defects around implants - A study in beagle dogs
The combined use of bioresorbable membranes and xenografts or autografts in the treatment of bone defects around implants - A study in beagle dogs
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DOI：
10.1034/j.1600-0501.1999.100607.x
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发表时间：
1999-12-01
影响因子：
4.3
通讯作者：
Hammerle, CHF
中科院分区：
文献类型：
--
作者：
Hockers, T;Abensur, D;Hammerle, CHF
本研究的目的是测试异种移植物或自体移植物支持的生物可吸收膜在植入物周围缺损中再生骨的作用。在3只犬中，双侧拔除下颌前磨牙P-2、P-3、P-4和M-1。愈合4个月后，在下颌骨的每一侧制备3个标准化骨缺损，每个缺损放置1个种植体。将每只犬的6个部位分为4个不同的治疗组：2个部位接受单独的Bio-Gide（R）膜（BG）; 2个部位接受由Bio-Oss（R）支撑的Bio-Gide（R）膜（BG+BO）; 1个部位接受由从制备的缺损处采集的自体骨支撑的Bio-Gide（R）膜（BG+Aut）; 1个部位既没有接受膜也没有接受骨移植，作为对照（C）。软组织瓣适应后缝合一期愈合。实验期间未发生不良事件。16周后，处死犬，对非脱钙研磨切片进行组织形态计量学检查。BG组的垂直骨生长占缺损高度的45%（SD+/-13%），BG+BO组为78%（SD+/-29%），BG+Aut组为69%（SD+/-9%），C组为22%（SD+/-10%）。BG组水平骨生长率为78%（SD+/-16%），BG+BO组为81%（SD+/-21%），BG+Aut组为82%（SD+/-12%），C组为46%（SD+/-21%）。BG组中与种植体接触的骨生长垂直高度为17%（SD+/-12%），BG+BO组为20%（SD+/-12%），BG+Aut组为17%（SD+/-7%），C组为12%（SD+/-8%）。BG+BO组和BG+Aut组直接骨接触的移植物表面分数分别为89%（SD+/-9%）和93%（SD+/-3%）。可以得出结论，测试的生物可吸收膜增强了骨再生，特别是与支持移植材料的使用相结合。此外，脱蛋白牛骨矿物质和自体骨移植物似乎同样很好地整合到再生骨中。最后，与羟基磷灰石相比，未观察到自体骨对骨生长的额外影响。
The aim of the present investigation was to test the effect of a bioresorbable membrane supported by xenografts or autografts in regenerating bone into peri-implant defects. In 3 dogs, the mandibular premolars P-2, P-3, P-4 and M-1 were extracted bilaterally. After 4 months of healing, 3 standardized bone defects were prepared on each side of the mandible and 1 implant per defect was placed. The 6 sites in each dog were distributed into 4 different treatment groups: 2 sites received a Bio-Gide(R) membrane alone (BG); 2 sites received a Bio-Gide(R) membrane supported by Bio-Oss(R) (BG+BO); 1 site received the Bio-Gide(R) membrane supported by autogenic bone harvested from the prepared defects (BG+Aut); 1 site received neither membrane nor bone graft and served as control (C). The soft tissue flaps were adapted and sutured for primary healing. No adverse events occurred during the experimental period. After 16 weeks, the dogs were sacrificed and histomorphometric examinations on non-decalcified ground sections were carried out. The vertical bone growth amounted to 45% (SD+/-13%) of the defect height in the BG group, to 78% (SD+/-29%) in the BG+BO group, to 69% (SD+/-9%) in the BG+Aut group, and to 22% (SD+/-10%) in C group. The horizontal bone growth measured 78% (SD+/-16%) in the BG group, 81% (SD+/-21%) in the BG+BO group, 82% (SD+/-12%) in the BG+Aut group, and 46% (SD+/-21%) in the C group. The vertical height of bone growth in contact with the implant measured 17% (SD+/-12%) in the BG group, 20% (SD+/-12%) in the BG+BO group, 17% (SD+/-7%) in the BG+Aut group, and 12% (SD+/-8%) in the C group. The surface fraction of the graft in direct bone contact measured 89% (SD+/-9%) in the BG+BO group and 93% (SD+/-3%) in the BG+Aut group. It is concluded thar the bioresorbable membrane tested enhances bone regeneration, in particular in conjunction with the use of a supporting graft material. In addition, deproteinized bovine bone mineral and autogenic bone grafts appeared to be equally well integrated into regenerating bone. Finally, no additional effects in the bone growth was observed with the autogenous bone in comparison with the hydroxyapatite.