Statistical inference for the area under the receiver operating characteristic curve in the presence of random measurement error
Statistical inference for the area under the receiver operating characteristic curve in the presence of random measurement error
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DOI：
10.1093/aje/154.2.174
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发表时间：
2001-07-15
影响因子：
5
通讯作者：
Trevisan, M
中科院分区：
文献类型：
--
作者：
Schisterman, EF;Faraggi, D;Trevisan, M
受试者工作特征曲线下的面积是生物标志物区分两个群体的能力的最常用的量度。一些标记物会受到相当大的测量误差的影响。在正态假设下，作者开发了接收器操作特征曲线下面积的置信区间程序，该程序根据测量误差进行调整。该程序假设生物标志物可靠性研究的数据可用。仿真研究被用来检查建议的置信区间的有效性。此外，研究表明，不调整测量误差可能导致严重低估生物标志物的有效性。
The area under the receiver operating characteristic curve is the most commonly used measure of the ability of a biomarker to distinguish between two populations. Some markers are subject to substantial measurement error. Under normality assumptions, the authors develop a confidence interval procedure for the area under the receiver operating characteristic curve that adjusts for measurement error. This procedure assumes the availability of data from a reliability study of the biomarker. A simulation study was used to check the validity of the proposed confidence interval. Furthermore, it was shown that not adjusting for measurement error could result in a serious understatement of the effectiveness of the biomarker.